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Role and potential of different T helper cell subsets in adoptive cell therapy.
Cancers 15:18 (2023)
Historically, CD8+ T cells have been considered the most relevant effector cells involved in the immune response against tumors and have therefore been the focus of most cancer immunotherapy approaches. However, CD4+ T cells and their secreted factors also play a crucial role in the tumor microenvironment and can orchestrate both pro- and antitumoral immune responses. Depending on the cytokine milieu to which they are exposed, CD4+ T cells can differentiate into several phenotypically different subsets with very divergent effects on tumor progression. In this review, we provide an overview of the current knowledge about the role of the different T helper subsets in the immune system, with special emphasis on their implication in antitumoral immune responses. Furthermore, we also summarize therapeutic applications of each subset and its associated cytokines in the adoptive cell therapy of cancer.
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Publication type
Article: Journal article
Document type
Review
Keywords
Cd4+ T Cell ; Adoptive Cell Therapy ; Cytokines ; Immunotherapy; Tumor-infiltrating Lymphocytes; Recombinant Human Interleukin-4; Th9 Cells; Th17 Cells; Antitumor Immunity; Dendritic Cells; Hepatocellular-carcinoma; Gene-therapy; Ifn-gamma; Tgf-beta
ISSN (print) / ISBN
2072-6694
Journal
Cancers
Quellenangaben
Volume: 15,
Issue: 6,
Article Number: 18
Publisher
MDPI
Publishing Place
St Alban-anlage 66, Ch-4052 Basel, Switzerland
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Unit for Clinical Pharmacology (KKG-EKLiP)