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Open Access Green as soon as Postprint is submitted to ZB.
Dynamics of nuclear architecture during early embryonic development and lessons from liveimaging.
Dev. Cell 58, 435-449 (2023)
Nuclear organization has emerged as a potential key regulator of genome function. During development, the deployment of transcriptional programs must be tightly coordinated with cell division and is often accompanied by major changes in the repertoire of expressed genes. These transcriptional and developmental events are paralleled by changes in the chromatin landscape. Numerous studies have revealed the dynamics of nuclear organization underlying them. In addition, advances in live-imaging-based methodologies enable the study of nuclear organization with high spatial and temporal resolution. In this Review, we summarize the current knowledge of the changes in nuclear architecture in the early embryogenesis of various model systems. Furthermore, to highlight the importance of integrating fixed-cell and live approaches, we discuss how different live-imaging techniques can be applied to examine nuclear processes and their contribution to our understanding of transcription and chromatin dynamics in early development. Finally, we provide future avenues for outstanding questions in this field.
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Publication type
Article: Journal article
Document type
Review
Keywords
Chromatin ; Embryo ; Epigenetics ; Imaging ; Nuclear Organization; Green Fluorescent Protein; Chromatin Architecture; Chromosome Domains; General-method; Dna-sequences; X-chromosome; Human Genome; Live-cell; Transcription; Organization
ISSN (print) / ISBN
1534-5807
e-ISSN
1878-1551
Journal
Developmental Cell
Quellenangaben
Volume: 58,
Issue: 6,
Pages: 435-449
Publisher
Elsevier
Publishing Place
50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epigenetics and Stem Cells (IES)
Grants
Humboldt Research Fellowship for Postdoctoral Researchers
NIH 4DN program
German Research Foundation (DFG)
Helmholtz Association
Humboldt Research Fellowship for Postdoctoral Researchers
NIH 4DN program
German Research Foundation (DFG)
Helmholtz Association