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Jüstel, D. ; Irl, H.* ; Hinterwimmer, F.* ; Dehner, C. ; Simson, W.* ; Navab, N.* ; Schneider, G.* ; Ntziachristos, V.

Spotlight on nerves: Portable multispectral optoacoustic imaging of peripheral nerve vascularization and morphology.

Adv. Sci. 10:e2301322 (2023)
DOI PMC
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Various morphological and functional parameters of peripheral nerves and their vascular supply are indicative of pathological changes due to injury or disease. Based on recent improvements in optoacoustic image quality, the ability of multispectral optoacoustic tomography, to investigate the vascular environment and morphology of peripheral nerves is explored in vivo in a pilot study on healthy volunteers in tandem with ultrasound imaging (OPUS). The unique ability of optoacoustic imaging to visualize the vasa nervorum by observing intraneural vessels in healthy nerves is showcased in vivo for the first time. In addition, it is demonstrated that the label-free spectral optoacoustic contrast of the perfused connective tissue of peripheral nerves can be linked to the endogenous contrast of hemoglobin and collagen. Metrics are introduced to analyze the composition of tissue based on its optoacoustic contrast and show that the high-resolution spectral contrast reveals specific differences between nervous tissue and reference tissue in the nerve's surrounding. How this showcased extraction of peripheral nerve characteristics using multispectral optoacoustic and ultrasound imaging could offer new insights into the pathophysiology of nerve damage and neuropathies, for example, in the context of diabetes is discussed.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Neuropathy ; Optoacoustic Imaging ; Peripheral Nerves ; Photoacoustic Imaging ; Spectral Unmixing; Response Characterization Method; Tomography; Ultrasound; Doppler
ISSN (print) / ISBN 2198-3844
e-ISSN 2198-3844
Journal Advanced science
Quellenangaben Volume: 10, Issue: 19, Pages: , Article Number: e2301322 Supplement: ,
Publisher Wiley
Publishing Place Weinheim
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
Institute of Computational Biology (ICB)
Grants
European Research Council (ERC)