PuSH - Publication Server of Helmholtz Zentrum München: Establishment and functional characterization of murine monoclonal antibodies recognizing neuritin.

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Papadogianni, G.* ; Ravens, I.* ; Hassan, A.* ; Flatley, A. ; Feederle, R. ; Bernhardt, G.* ; Georgiev, H.*

Establishment and functional characterization of murine monoclonal antibodies recognizing neuritin.

Antibodies 12:9 (2023)

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Neuritin represents a neurotrophic factor that is not only important in neuronal development and plasticity but also impacts endothelial angiogenesis, cell migration, tumor growth and the production of antibodies by B cells. We established monoclonal mouse anti-mouse neuritin antibodies by immunizing knock-out mice with two different neuritin-derived peptides. Because neuritin is well conserved between species, these new monoclonal antibodies recognize the neuritin of a wide variety of species, including human. Moreover, they not only recognize specifically surface-bound neuritin expressed by murine follicular regulatory T cells but also the block binding of recombinant neuritin to germinal center B cells. This suggests that these newly generated tools will be of great use in studying neuritin expression and function.

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