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Establishment and functional characterization of murine monoclonal antibodies recognizing neuritin.
Antibodies 12:9 (2023)
Neuritin represents a neurotrophic factor that is not only important in neuronal development and plasticity but also impacts endothelial angiogenesis, cell migration, tumor growth and the production of antibodies by B cells. We established monoclonal mouse anti-mouse neuritin antibodies by immunizing knock-out mice with two different neuritin-derived peptides. Because neuritin is well conserved between species, these new monoclonal antibodies recognize the neuritin of a wide variety of species, including human. Moreover, they not only recognize specifically surface-bound neuritin expressed by murine follicular regulatory T cells but also the block binding of recombinant neuritin to germinal center B cells. This suggests that these newly generated tools will be of great use in studying neuritin expression and function.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Elisa ; Blocking Antibody ; Flow Cytometry ; Monoclonal Antibody ; Neuritin; Cpg15; Growth
ISSN (print) / ISBN
2073-4468
e-ISSN
2073-4468
Journal
Antibodies
Quellenangaben
Volume: 12,
Issue: 2,
Article Number: 9
Publisher
MDPI
Publishing Place
St Alban-anlage 66, Ch-4052 Basel, Switzerland
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
CF Monoclonal Antibodies (CF-MAB)