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Small, K.S.* ; Hedman, A.K.* ; Grundberg, E.* ; Nica, A.C.* ; Thorleifsson, G.* ; Kong, A.* ; Thorsteindottir, U.* ; Shin, S.Y.* ; Richards, H.B* ; GIANT Consortium (Peters, A. ; Thiering, E. ; Grallert, H. ; Gieger, C. ; Heid, I.M. ; Wichmann, H.-E. ; Illig, T. ; Heinrich, J.) ; MAGIC Investigators (Grallert, H. ; Meisinger, C. ; Gieger, C. ; Thorand, B. ; Wichmann, H.-E. ; Illig, T.) ; DIAGRAM Consortium (Huth, C. ; Grallert, H. ; Gieger, C. ; Klopp, N. ; Meitinger, T. ; Petersen, A.-K. ; Thorand, B. ; Wichmann, H.-E. ; Illig, T.) ; Soranzo, N.* ; Ahmadi, K.R.* ; Lindgren, C.M.* ; Stefansson, K.* ; Dermitzakis, E.T.* ; Deloukas, P.* ; Spector, T.D.* ; McCarthy, M.I.* ; MuTHER Consortium (*)

Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes.

Nat. Genet. 43, 561-564 (2011)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Genome-wide association studies have identified many genetic variants associated with complex traits. However, at only a minority of loci have the molecular mechanisms mediating these associations been characterized. In parallel, whereas cis regulatory patterns of gene expression have been extensively explored, the identification of trans regulatory effects in humans has attracted less attention. Here we show that the type 2 diabetes and high-density lipoprotein cholesterol-associated cis-acting expression quantitative trait locus (eQTL) of the maternally expressed transcription factor KLF14 acts as a master trans regulator of adipose gene expression. Expression levels of genes regulated by this trans-eQTL are highly correlated with concurrently measured metabolic traits, and a subset of the trans-regulated genes harbor variants directly associated with metabolic phenotypes. This trans-eQTL network provides a mechanistic understanding of the effect of the KLF14 locus on metabolic disease risk and offers a potential model for other complex traits.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Wide association analysis; Body-mass index; Transciption factors; Insulin-resistance; Twin cohort; Variants; Diseases; Risk
Language english
Publication Year 2011
HGF-reported in Year 2011
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 43, Issue: 6, Pages: 561-564 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Research Unit Molecular Epidemiology (AME)
Institute of Epidemiology (EPI)
Institute of Genetic Epidemiology (IGE)
Institute of Human Genetics (IHG)
POF-Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30202 - Environmental Health
30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504200-002
G-504000-002
G-504100-001
G-500700-001
G-503900-001
PubMed ID 21572415
DOI 10.1038/ng.833
Erfassungsdatum 2011-12-08
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