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Annesi-Maesano, I.* ; Cecchi, L.* ; Biagioni, B.* ; Chung, K.F.* ; Clot, B.* ; Collaud Coen, M.* ; D'Amato, G.* ; Damialis, A.* ; Dominguez-Ortega, J.* ; Galan, C.* ; Gilles, S.* ; Holgate, S.* ; Jeebhay, M.* ; Kazadzis, S.* ; Papadopoulos, N.G.* ; Quirce, S.* ; Sastre, J.* ; Tummon, F.* ; Traidl-Hoffmann, C. ; Walusiak-Skorupa, J.* ; Alonso-Coello, P.* ; Canelo-Aybar, C.* ; Cantero-Fortiz, Y.* ; Rigau, D.* ; Salazar, J.* ; Verdugo-Paiva, F.* ; Jutel, M.* ; Akdis, C.A.* ; Agache, I.*

Is exposure to pollen a risk factor for moderate and severe asthma exacerbations?

Allergy 78, 2121-2147 (2023)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Limited number of studies have focused on the impact of pollen exposure on asthma. As a part of the EAACI Guidelines on Environment Science, this first systematic review on the relationship of pollen exposure to asthma exacerbations aimed to bridge this knowledge gap in view of implementing recommendations of prevention. We searched electronic iPubMed, Embase, and Web of Science databases using a set of MeSH terms and related synonyms and identified 73 eligible studies that were included for systemic review. When possible, meta-analyses were conducted. Overall meta-analysis suggests that outdoor pollen exposure may have an effect on asthma exacerbation, but caution is needed due to the low number of studies and their heterogeneity. The strongest associations were found between asthma attacks, asthma-related ED admissions or hospitalizations, and an increase in grass pollen concentration in the previous 2-day overall in children aged less than 18 years of age. Tree pollen may increase asthma-related ED visits or admissions lagged up to 7-day overall in individuals younger than 18 years. Rare data show that among subjects under 18 years of age, an exposure to grass pollen lagged up to 3 days may lower lung function. Further research considering effect modifiers of pollen sensitization, hay fever, asthma, air pollution, green spaces, and pre-existing medications is urgently warranted to better evaluate the impacts of pollen on asthma exacerbation. Preventive measures in relation to pollen exposure should be integrated in asthma control as pollen increase continues due to climate change.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Aerobiology ; Asthma ; Pollen; Thunderstorm-associated Asthma; Emergency-department Visits; Airborne Grass-pollen; Bell Pepper Pollen; Ole E 1; Occupational Allergy; Air-pollution; Major Allergen; Tree Pollen; Hospital Admissions
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Quellenangaben Volume: 78, Issue: 8, Pages: 2121-2147 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Environmental Medicine (IEM)