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Single-cell profiling to explore pancreatic cancer heterogeneity, plasticity and response to therapy.
Nat. Cancer 4, 454-467 (2023)
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer entity characterized by a heterogeneous genetic landscape and an immunosuppressive tumor microenvironment. Recent advances in high-resolution single-cell sequencing and spatial transcriptomics technologies have enabled an in-depth characterization of both malignant and host cell types and increased our understanding of the heterogeneity and plasticity of PDAC in the steady state and under therapeutic perturbation. In this Review we outline single-cell analyses in PDAC, discuss their implications on our understanding of the disease and present future perspectives of multimodal approaches to elucidate its biology and response to therapy at the single-cell level.
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Publication type
Article: Journal article
Document type
Review
Keywords
Ductal Adenocarcinoma; Fibroblasts; Tumor; Rna; Immunosuppression; Subtypes; Microenvironment; Inhibition; Genomics; Seq
ISSN (print) / ISBN
2662-1347
e-ISSN
2662-1347
Journal
Nature Cancer
Quellenangaben
Volume: 4,
Issue: 4,
Pages: 454-467
Publisher
Springer
Publishing Place
Heidelberger Platz 3, Berlin, 14197, Germany
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Computational Biology (ICB)
Grants
Deutsche Forschungsgemeinschaft
German Cancer Consortium
Wilhelm Sander-Stiftung
European Research Council (ERC CoG )
Cancer Research Institute
German Cancer Consortium
Wilhelm Sander-Stiftung
European Research Council (ERC CoG )
Cancer Research Institute