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Karlas, A. ; Fasoula, N.-A. ; Katsouli, N. ; Kallmayer, M.* ; Sieber, S.* ; Schmidt, S.* ; Liapis, E. ; Halle, M.* ; Eckstein, H.H.* ; Ntziachristos, V.

Skeletal muscle optoacoustics reveals patterns of circulatory function and oxygen metabolism during exercise.

Photoacoustics 30:100468 (2023)

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Imaging skeletal muscle function and metabolism, as reported by local hemodynamics and oxygen kinetics, can elucidate muscle performance, severity of an underlying disease or outcome of a treatment. Herein, we used multispectral optoacoustic tomography (MSOT) to image hemodynamics and oxygen kinetics within muscle during exercise. Four healthy volunteers underwent three different hand-grip exercise challenges (60s isometric, 120s intermittent isometric and 60s isotonic). During isometric contraction, MSOT showed a decrease of HbO₂, Hb and total blood volume (TBV), followed by a prominent increase after the end of contraction. Corresponding hemodynamic behaviors were recorded during the intermittent isometric and isotonic exercises. A more detailed analysis of MSOT readouts revealed insights into arteriovenous oxygen differences and muscle oxygen consumption during all exercise schemes. These results demonstrate an excellent capability of visualizing both circulatory function and oxygen metabolism within skeletal muscle under exercise, with great potential implications for muscle research, including relevant disease diagnostics.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Hb, Deoxygenated Hemoglobin ; Hbo2, Oxygenated Hemoglobin ; Hemodynamics ; Msot ; Msot, Multispectral Optoacoustic Tomography ; Mvc, Maximum Voluntary Contraction ; Metabolic Imaging ; Multispectral Optoacoustic Tomography ; Musculoskeletal Physiology ; Oxygenation ; Pad, Peripheral Arterial Disease ; Photoacoustics ; Tbv, Total Blood Volume; Contrast-enhanced Ultrasound; Near-infrared Spectroscopy; Blood-flow; Tomography; Inversion; Perfusion; Pressure; Mri

ISSN (print) / ISBN 2213-5979

Journal Photoacoustics

Quellenangaben Volume: 30, Article Number: 100468

Publisher Elsevier

Publishing Place Hackerbrucke 6, 80335 Munich, Germany

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Biological and Medical Imaging (IBMI)

Grants European Research Council (ERC)
Helmholtz Zentrum Muenchen funding program "Physician Scientists for Groundbreaking Projects"
DZHK (German Centre for Cardiovascular Research)