Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Bitter taste cells in the ventricular walls of the murine brain regulate glucose homeostasis.
Nat. Commun. 14:1588 (2023)
The median eminence (ME) is a circumventricular organ at the base of the brain that controls body homeostasis. Tanycytes are its specialized glial cells that constitute the ventricular walls and regulate different physiological states, however individual signaling pathways in these cells are incompletely understood. Here, we identify a functional tanycyte subpopulation that expresses key taste transduction genes including bitter taste receptors, the G protein gustducin and the gustatory ion channel TRPM5 (M5). M5 tanycytes have access to blood-borne cues via processes extended towards diaphragmed endothelial fenestrations in the ME and mediate bidirectional communication between the cerebrospinal fluid and blood. This subpopulation responds to metabolic signals including leptin and other hormonal cues and is transcriptionally reprogrammed upon fasting. Acute M5 tanycyte activation induces insulin secretion and acute diphtheria toxin-mediated M5 tanycyte depletion results in impaired glucose tolerance in diet-induced obese mice. We provide a cellular and molecular framework that defines how bitter taste cells in the ME integrate chemosensation with metabolism.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Arcuate Nucleus; Messenger-rna; Food-intake; Tanycytes; Ablation; Protein; Mice; Expression; Plasticity; Receptors
ISSN (print) / ISBN
2041-1723
e-ISSN
2041-1723
Journal
Nature Communications
Quellenangaben
Volume: 14,
Issue: 1,
Article Number: 1588
Publisher
Nature Publishing Group
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)
Grants
European Research Council (ERC)
DFG and Saarland University
Deutsche Forschungsgemeinschaft (DFG)
DFG and Saarland University
Deutsche Forschungsgemeinschaft (DFG)