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Hoffmann, C.* ; Schwarz, P.E. ; Mantzoros, C.S.* ; Birkenfeld, A.L. ; Wolfrum, C.* ; Solimena, M. ; Bornstein, S.R. ; Perakakis, N.

Circulating levels of gastrointestinal hormones in prediabetes reversing to normoglycemia or progressing to diabetes in a year-A cross-sectional and prospective analysis.

Diabetes Res. Clin. Pract. 199:110636 (2023)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
AIMS: We aimed to compare the concentrations of GLP-1, glucagon and GIP (established regulators of glucose homeostasis) and glicentin (emerging new metabolic marker)during an OGTT in patients with normal glucose tolerance (NGT), prediabetes and diabetes at onset, and one-year before, when all had prediabetes. METHODS: GLP-1, glucagon, GIP and glicentin concentrations were measured and compared with markers of body composition, insulin sensitivity and β-cell function at a 5-timepoint OGTT in 125 subjects (30 diabetes, 65 prediabetes, 30 NGT) and in 106 of them one-year before, when all had prediabetes. RESULTS: At baseline, when all subjects were in prediabetic state, hormonal levels did not differ between groups. One year later, patients progressing to diabetes had lower postprandial increases of glicentin and GLP-1, lower postprandial decrease of glucagon, and higher levels of fasting GIP compared to patients regressing to NGT. Changes in glicentin and GLP-1 AUC within this year correlated negatively with changes in Glucose AUC of OGTT and with changes in markers of beta cell function. CONCLUSION: Incretins, glucagon and glicentin profiles in prediabetic state cannot predict future glycemic traits, but prediabetes progressing to diabetes is accompanied by deterioration of postprandial increases of GLP-1 and glicentin.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Incretins ; Proglucagon-derived Peptides ; Type 2 Diabetes Mellitus; Glucagon-like Peptide-1; Dependent Insulinotropic Polypeptide; Commercially Available Assays; Oral Glucose; Type-2; Glp-1; Specificity; Sensitivity; Secretion
ISSN (print) / ISBN 0168-8227
e-ISSN 1872-8227
Journal Diabetes Research and Clinical Practice
Quellenangaben Volume: 199, Issue: , Pages: , Article Number: 110636 Supplement: ,
Publisher Elsevier
Publishing Place Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)
Institute of Diabetes Research and Metabolic Diseases (IDM)
Grants BundesministeriumfrBildung und Foschung (BMBF) - DeutschesZen-trumfrDiabetesforschung
Deutsche Foschungsgemeinschaft (DFG)