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Wissmiller, K. ; Bilekova, S. ; Frankó, A. ; Lutz, S.Z.* ; Katsburg, M. ; Gulde, S. ; Pellegata, N.S. ; Stenzl, A.* ; Heni, M. ; Berti, L. ; Häring, H.-U. ; Lickert, H.

Inceptor correlates with markers of prostate cancer progression and modulates insulin/IGF1 signaling and cancer cell migration.

Mol. Metab. 71:101706 (2023)
DOI PMC
Creative Commons Lizenzvertrag
Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
OBJECTIVE: The insulin/insulin-like growth factor 1 (IGF1) pathway is emerging as a crucial component of prostate cancer progression. Therefore, we investigated the role of the novel insulin/IGF1 signaling modulator inceptor in prostate cancer. METHODS: We analyzed the expression of inceptor in human samples of benign prostate epithelium and prostate cancer. Further, we performed signaling and functional assays using prostate cancer cell lines. RESULTS: We found that inceptor was expressed in human benign and malignant prostate tissue and its expression positively correlated with various genes of interest, including genes involved in androgen signaling. In vitro, total levels of inceptor were increased upon androgen deprivation and correlated with high levels of androgen receptor in the nucleus. Inceptor overexpression was associated with increased cell migration, altered IGF1R trafficking and higher IGF1R activation. CONCLUSIONS: Our in vitro results showed that inceptor expression was associated with androgen status, increased migration, and IGF1R signaling. In human samples, inceptor expression was significantly correlated with markers of prostate cancer progression. Taken together, these data provide a basis for investigation of inceptor in the context of prostate cancer.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Androgen ; Igf1r ; Insulin ; Signaling ; Trafficking; Growth-factor-i; Diet-induced Hyperinsulinemia; Androgen Receptor Gene; Membrane Antigen; Neuroendocrine Differentiation; Expression; Activation; Inhibition; Mortality; Estrogen
ISSN (print) / ISBN 2212-8778
e-ISSN 2212-8778
Journal Molecular Metabolism
Quellenangaben Volume: 71, Issue: , Pages: , Article Number: 101706 Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Regeneration Research (IDR)
Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute of Diabetes and Cancer (IDC)