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Steenblock, C.* ; Toepfner, N.* ; Beuschlein, F.* ; Perakakis, N. ; Mohan Anjana, R.* ; Mohan, V.* ; Mahapatra, N.R.* ; Bornstein, S.R.*

SARS-CoV-2 infection and its effects on the endocrine system.

Best Pract. Res. Clin. Endocrinol. Metab. 37:101761 (2023)
Postprint DOI PMC
Open Access Green
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing corona virus disease 2019 (COVID-19) can infect multiple tissues, including endocrine organs, such as the pancreas, adrenal, thyroid, and adipose tissue. The main receptor for SARS-CoV-2, ACE2, is ubiquitously expressed in the cells of the endocrine organs and accordingly, the virus has been detected in various amounts in all endocrine tissues in post-mortem samples from COVID-19 patients. The infection with SARS-CoV-2 may directly lead to organ damage or dysfunction, such as hyperglycaemia or in rare cases, new-onset diabetes. Furthermore, an infection with SARS-CoV-2 may have indirect effects affecting the endocrine system. The exact mechanisms are not yet completely understood and have to be further investigated. Conversely, endocrine diseases may affect the severity of COVID-19 and emphasis has to be laid on reducing the prevalence, or enhance the treatment, of these often non-communicable diseases in the future.
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Publication type Article: Journal article
Document type Review
Keywords Ace2 ; Covid-19 ; Sars-cov-2 ; Autoimmune ; Endocrine ; Metabolic; Adipose-tissue; Covid-19; Ace2
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 1521-690X
e-ISSN 1532-1908
Journal Best Practice and Research Clinical Endocrinology and Metabolism
Quellenangaben Volume: 37, Issue: 4, Pages: , Article Number: 101761 Supplement: ,
Publisher Elsevier
Publishing Place The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
Reviewing status Peer reviewed
Institute(s) Institute of Pancreatic Islet Research (IPI)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502600-012
Grants German Research Foundation (DFG)
DOI 10.1016/j.beem.2023.101761
WOS ID 001046845400001
PubMed ID 36907787
Erfassungsdatum 2023-10-06
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