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SARS-CoV-2 infection and its effects on the endocrine system.
Best Pract. Res. Clin. Endocrinol. Metab. 37:101761 (2023)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing corona virus disease 2019 (COVID-19) can infect multiple tissues, including endocrine organs, such as the pancreas, adrenal, thyroid, and adipose tissue. The main receptor for SARS-CoV-2, ACE2, is ubiquitously expressed in the cells of the endocrine organs and accordingly, the virus has been detected in various amounts in all endocrine tissues in post-mortem samples from COVID-19 patients. The infection with SARS-CoV-2 may directly lead to organ damage or dysfunction, such as hyperglycaemia or in rare cases, new-onset diabetes. Furthermore, an infection with SARS-CoV-2 may have indirect effects affecting the endocrine system. The exact mechanisms are not yet completely understood and have to be further investigated. Conversely, endocrine diseases may affect the severity of COVID-19 and emphasis has to be laid on reducing the prevalence, or enhance the treatment, of these often non-communicable diseases in the future.
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Publication type
Article: Journal article
Document type
Review
Keywords
Ace2 ; Covid-19 ; Sars-cov-2 ; Autoimmune ; Endocrine ; Metabolic; Adipose-tissue; Covid-19; Ace2
ISSN (print) / ISBN
1521-690X
e-ISSN
1532-1908
Quellenangaben
Volume: 37,
Issue: 4,
Article Number: 101761
Publisher
Elsevier
Publishing Place
The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)
Grants
German Research Foundation (DFG)