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Jayakodi, M.* ; Golicz, A.A.* ; Kreplak, J.* ; Fechete, L.I.* ; Angra, D.* ; Bednář, P.* ; Bornhofen, E.* ; Zhang, H.* ; Boussageon, R.* ; Kaur, S.* ; Cheung, K.* ; Čížková, J.* ; Gundlach, H. ; Hallab, A.* ; Imbert, B.* ; Keeble-Gagnère, G.* ; Koblížková, A.* ; Kobrlová, L.* ; Krejčí, P.* ; Mouritzen, T.W.* ; Neumann, P.* ; Nadzieja, M.* ; Nielsen, L.K.* ; Novak, P.* ; Orabi, J.* ; Padmarasu, S.* ; Robertson-Shersby-Harvie, T.* ; Robledillo, L.* ; Schiemann, A.* ; Tanskanen, J.* ; Törönen, P.* ; Warsame, A.O.* ; Wittenberg, A.H.J.* ; Himmelbach, A.* ; Aubert, G.* ; Courty, P.E.* ; Dolezel, J.* ; Holm, L.U.* ; Janss, L.L.* ; Khazaei, H.* ; Macas, J.* ; Mascher, M.* ; Smýkal, P.* ; Snowdon, R.J.* ; Stein, N.* ; Stoddard, F.L.* ; Stougaard, J.* ; Tayeh, N.* ; Torres, A.M.* ; Usadel, B.* ; Schubert, I.* ; O'Sullivan, D.M.* ; Schulman, A.H.* ; Andersen, S.U.*

The giant diploid faba genome unlocks variation in a global protein crop.

Nature 615, 652-659 (2023)
Postprint DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Increasing the proportion of locally produced plant protein in currently meat-rich diets could substantially reduce greenhouse gas emissions and loss of biodiversity1. However, plant protein production is hampered by the lack of a cool-season legume equivalent to soybean in agronomic value2. Faba bean (Vicia faba L.) has a high yield potential and is well suited for cultivation in temperate regions, but genomic resources are scarce. Here, we report a high-quality chromosome-scale assembly of the faba bean genome and show that it has expanded to a massive 13 Gb in size through an imbalance between the rates of amplification and elimination of retrotransposons and satellite repeats. Genes and recombination events are evenly dispersed across chromosomes and the gene space is remarkably compact considering the genome size, although with substantial copy number variation driven by tandem duplication. Demonstrating practical application of the genome sequence, we develop a targeted genotyping assay and use high-resolution genome-wide association analysis to dissect the genetic basis of seed size and hilum colour. The resources presented constitute a genomics-based breeding platform for faba bean, enabling breeders and geneticists to accelerate the improvement of sustainable protein production across the Mediterranean, subtropical and northern temperate agroecological zones.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Nuclear-dna Content; Sequence; Program; Package; Model; Size; Identification; Calculator; Discovery; Selection
ISSN (print) / ISBN 0028-0836
e-ISSN 1476-4687
Journal Nature
Quellenangaben Volume: 615, Issue: 7953, Pages: 652-659 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Research Unit Plant Genome and Systems Biology (PGSB)
Grants FACCE-JPI ERA-NET SusCrop Profaba
German Leibniz Association
German Federal Ministry of Education and Research (de.NBI)
Novo Nordisk Fund
Jane and Aatos Erkko Foundation grant (PanFaba)
Alexander von Humboldt Foundation
Biotechnology and Biological Sciences Research Council
German Research Foundation (DFG)
Czech Science Foundation
European Research Council under the European Union's Horizon 2020 research and innovation programme
BMBF
Innovation Fund Denmark
Grains Research Development Corporation
Agriculture Victoria for PacBio sequencing, parts of the public dataset curation for pulses. plantinformatics.io
RNA sequencing data (BioProject)
Czech Ministry of Education, Youth and Sports
European Research Council (ERC)