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EJE Prize 2023: Genes on steroids-genomic control of hepatic metabolism by the glucocorticoid receptor.
Eur. J. Endocrinol. 188, R111-R130 (2023)
Glucocorticoids are essential hormones produced by the adrenal cortex with prominent circadian rhythmicity and in times of stress. Glucocorticoids maintain liver homeostasis through coordinated activities that control the major pathways of energy metabolism. Glucocorticoids activate the glucocorticoid receptor (GR), a nuclear hormone receptor that regulates the transcription of hundreds of genes in response to ligand. This review aims to provide a comprehensive overview of glucocorticoid receptor signaling impact on glucose, amino acid, and lipid metabolism in the liver. We integrate fundamental and current findings elucidating key GR-regulated pathways from a physiologic, biochemical, and molecular point-of-view. Here, we focus on the transcriptional regulation of well-characterized hepatic GR target genes, and on those GR co-factors that coordinate nutritional and hormonal signals.
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Publication type
Article: Journal article
Document type
Review
Keywords
Glucocorticoid Receptor ; Hormones ; Liver Metabolism ; Transcription; Phosphoenolpyruvate Carboxykinase Gene; Low-density-lipoprotein; Urea-cycle Enzymes; Alpha-ketoglutarate Transaminase; Tyrosine Aminotransferase Gene; Messenger-rna Levels; Very-low-density; Rev-erb-alpha; Tryptophan Oxygenase Gene; Activated Protein-kinase
ISSN (print) / ISBN
0804-4643
e-ISSN
1479-683X
Quellenangaben
Volume: 188,
Issue: 5,
Pages: R111-R130
Publisher
BioScientifica
Publishing Place
Great Clarendon St, Oxford Ox2 6dp, England
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Endocrinology (IDE)