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Meen, A.J.* ; Doncheva, A.I.* ; Böttcher, Y.* ; Dankel, S.N.* ; Hoffmann, A. ; Blüher, M. ; Fernø, J.* ; Mellgren, G.* ; Ghosh, A.* ; Sun, W.* ; Dong, H.* ; Noé, F.* ; Wolfrum, C.* ; Pejler, G.* ; Dalen, K.T.* ; Kolset, S.O.*

Obesity is associated with distorted proteoglycan expression in adipose tissue.

Int. J. Mol. Sci. 24:12 (2023)
Publ. Version/Full Text DOI PMC
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Proteoglycans are central components of the extracellular matrix (ECM) and binding partners for inflammatory chemokines. Morphological differences in the ECM and increased inflammation are prominent features of the white adipose tissues in patients with obesity. The impact of obesity and weight loss on the expression of specific proteoglycans in adipose tissue is not well known. This study aimed to investigate the relationship between adiposity and proteoglycan expression. We analyzed transcriptomic data from two human bariatric surgery cohorts. In addition, RT-qPCR was performed on adipose tissues from female and male mice fed a high-fat diet. Both visceral and subcutaneous adipose tissue depots were analyzed. Adipose mRNA expression of specific proteoglycans, proteoglycan biosynthetic enzymes, proteoglycan partner molecules, and other ECM-related proteins were altered in both human cohorts. We consistently observed more profound alterations in gene expression of ECM targets in the visceral adipose tissues after surgery (among others VCAN (p = 0.000309), OGN (p = 0.000976), GPC4 (p = 0.00525), COL1A1 (p = 0.00221)). Further, gene analyses in mice revealed sex differences in these two tissue compartments in obese mice. We suggest that adipose tissue repair is still in progress long after surgery, which may reflect challenges in remodeling increased adipose tissues. This study can provide the basis for more mechanistic studies on the role of proteoglycans in adipose tissues in obesity.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Adipose Tissue ; Extracellular Matrix ; Inflammation ; Obesity ; Proteoglycans; Collagen Vi; Weight-loss; Inflammation; Fibrosis; Col6a3; Resistance; Serglycin
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 1661-6596
e-ISSN 1422-0067
Journal International Journal of Molecular Sciences
Quellenangaben Volume: 24, Issue: 8, Pages: , Article Number: 12 Supplement: ,
Publisher MDPI
Publishing Place Basel
Reviewing status Peer reviewed
Institute(s) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-506501-001
Grants
Trond Mohn Stiftelse
Deutsches Zentrum fur Diabetesforschung
Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
Western Norway Regional Health Authority (Helse Vest RHF)
Throne Holst Foundation
Institute of Basic Medical Sciences, University of Oslo
DOI 10.3390/ijms24086884
WOS ID 000979099800001
Scopus ID 85156239405
PubMed ID 37108048
Erfassungsdatum 2023-10-06
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