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EAACI Molecular Allergology User's Guide 2.0.
Pediatr. Allergy Immunol. 34 Suppl 28:e13854 (2023)
Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE-mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE-mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well-defined, highly pure molecules for component-resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the "EAACI Molecular Allergology User's Guide" (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state-of-the-art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure.
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Publication type
Article: Journal article
Document type
Review
Keywords
Ige ; Ige Cross-reactivity ; Allergy ; Allergy Diagnosis ; Anaphylaxis ; Asthma ; Atopic Dermatitis ; Basophil Activation Test ; Component-resolved Diagnosis ; Cross-reactive Carbohydrates ; Diagnostic Algorithms ; Food Allergy ; Gibberellin-regulated Proteins ; Lipocalins ; Microarray ; Molecular Allergology ; Non-specific Lipid Transfer Proteins ; Oleosins ; Pan-allergens ; Parvalbumins ; Pathogenesis-related Protein Family 10 ; Polcalcins ; Pollen Allergy ; Precision Medicine ; Profilins ; Seed Storage P; Component-resolved Diagnosis; House-dust Mite; Lipid Transfer Protein; Bet V 1; Basophil Activation Test; Birch Pollen Allergen; Reactive Carbohydrate Determinants; Skin Prick Test; Cows Milk Allergy; Red Meat Allergy
ISSN (print) / ISBN
0905-6157
e-ISSN
1399-3038
Journal
Pediatric Allergy and Immunology
Quellenangaben
Volume: 34 Suppl 28,
Issue: S28,
Article Number: e13854
Publisher
Wiley
Publishing Place
111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Allergy Research (IAF)
Grants
Biotechnology and Biological Sciences Research Council
Wellcome Trust
Wellcome Trust