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Rani, R.* ; Raina, N.* ; Sharma, A.* ; Kumar, P. ; Tulli, H.S.* ; Gupta, M.*

Advancement in nanotechnology for treatment of rheumatoid arthritis: Scope and potential applications.

Naunyn-Schmiedebergs Arch. Pharmakol. 396, 2287-2310 (2023)
Postprint DOI PMC
Open Access Green
Rheumatoid arthritis is a hyperactive immune disorder that results in severe inflammation in synovial joints, cartilage, and bone deterioration, resulting in immobilization of joints. Traditional approaches for the treatment of rheumatoid arthritis are associated with some limiting factors such as suboptimal patient compliance, inability to control the progression of disorder, and safety concerns. Therefore, innovative drug delivery carriers for efficient therapeutic delivery at inflamed synovial sites with better safety assessment are urgently needed to address these issues. From this perspective, nanotechnology is an outstanding alternative to traditional drug delivery approaches, and it has shown great promise in developing novel carriers to treat rheumatoid arthritis. Considering the current research and future application of nanocarriers, it is believed that nanocarriers can be a crucial element in rheumatoid arthritis treatment. This paper covers all currently available pathophysiological aspects of rheumatoid arthritis and treatment options. Future research for the reduction of synovial inflammation should focus on developing multifunction nanoparticles capable of delivering therapeutic agents with improved safety, efficacy, and cost-effectiveness to be commercialized.
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Publication type Article: Journal article
Document type Review
Keywords Animal Models ; Biological Agents ; Nanocarriers ; Nanotechnology ; Rheumatoid Arthritis ; Targeted Therapy; Collagen-induced Arthritis; Solid Lipid Nanoparticles; Adjuvant-induced Arthritis; T-cell-receptor; Nf-kappa-b; Drug-delivery; Polymeric Micelles; Topical Delivery; Rat Model; Disease
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 0028-1298
e-ISSN 1432-1912
Journal Naunyn-Schmiedeberg's Archives of Pharmacology
Quellenangaben Volume: 396, Issue: 10, Pages: 2287-2310 Article Number: , Supplement: ,
Publisher Springer
Publishing Place One New York Plaza, Suite 4600, New York, Ny, United States
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-505000-008
DOI 10.1007/s00210-023-02514-5
WOS ID 000986039200001
Scopus ID 85159128016
PubMed ID 37166463
Erfassungsdatum 2023-10-06
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