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Open Access Green as soon as Postprint is submitted to ZB.
Advancement in nanotechnology for treatment of rheumatoid arthritis: Scope and potential applications.
Naunyn-Schmiedebergs Arch. Pharmakol. 396, 2287-2310 (2023)
Rheumatoid arthritis is a hyperactive immune disorder that results in severe inflammation in synovial joints, cartilage, and bone deterioration, resulting in immobilization of joints. Traditional approaches for the treatment of rheumatoid arthritis are associated with some limiting factors such as suboptimal patient compliance, inability to control the progression of disorder, and safety concerns. Therefore, innovative drug delivery carriers for efficient therapeutic delivery at inflamed synovial sites with better safety assessment are urgently needed to address these issues. From this perspective, nanotechnology is an outstanding alternative to traditional drug delivery approaches, and it has shown great promise in developing novel carriers to treat rheumatoid arthritis. Considering the current research and future application of nanocarriers, it is believed that nanocarriers can be a crucial element in rheumatoid arthritis treatment. This paper covers all currently available pathophysiological aspects of rheumatoid arthritis and treatment options. Future research for the reduction of synovial inflammation should focus on developing multifunction nanoparticles capable of delivering therapeutic agents with improved safety, efficacy, and cost-effectiveness to be commercialized.
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Publication type
Article: Journal article
Document type
Review
Keywords
Animal Models ; Biological Agents ; Nanocarriers ; Nanotechnology ; Rheumatoid Arthritis ; Targeted Therapy; Collagen-induced Arthritis; Solid Lipid Nanoparticles; Adjuvant-induced Arthritis; T-cell-receptor; Nf-kappa-b; Drug-delivery; Polymeric Micelles; Topical Delivery; Rat Model; Disease
ISSN (print) / ISBN
0028-1298
e-ISSN
1432-1912
Quellenangaben
Volume: 396,
Issue: 10,
Pages: 2287-2310
Publisher
Springer
Publishing Place
One New York Plaza, Suite 4600, New York, Ny, United States
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Lung Health and Immunity (LHI)