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Open Access Green as soon as Postprint is submitted to ZB.
Basophil activation test in double-sensitized patients with hymenoptera venom allergy: Additional benefit of component-resolved diagnostics.
J. Allergy Clin. Immunol. Pract. 11, 2890-2899.e2 (2023)
BACKGROUND: In Hymenoptera venom allergy serologically double-sensitized patients, it is often difficult to identify the culprit insect for venom immunotherapy (VIT). OBJECTIVES: To evaluate if basophil activation tests (BATs) performed not only with venom extracts but additionally with single component-resolved diagnostics could differentiate between sensitized and allergic individuals and how the test results influenced the physicians' decision regarding VIT. METHODS: BATs were performed with bee and wasp venom extracts and with single components (Api m 1, Api m 10, Ves v 1, and Ves v 5) in 31 serologically double-sensitized patients. RESULTS: In 28 finally included individuals, 9 BATs were positive and 4 negative for both venoms. Fourteen of 28 BATs showed positive results for wasp venom alone. Two of 10 BATs positive for bee venom were only positive to Api m 1 and 1 of 28 BATs only to Api m 10, but not for whole bee venom extract. Five of 23 BATs positive for wasp venom were only positive for Ves v 5 but negative for wasp venom extract and Ves v 1. Finally, VIT with both insect venoms was recommended in 4 of 28 individuals, with wasp venom alone in 21 of 28 patients and with bee venom alone in 1 of 28. In 2 cases no VIT was recommended. CONCLUSIONS: BATs with Ves v 5, followed by Api m 1 and Api m 10, were helpful for the decision for VIT with the clinically relevant insect in 8 of 28 (28.6%) patients. A BAT with components should therefore be additionally carried out in cases with equivocal results.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Api M 1 ; Api M 10 ; Basophil Activation Test ; Hymenoptera Venom Allergy ; Molecular Allergens ; Venom Immunotherapy ; Ves V 1 ; Ves V 5; Api M 1; Rves V 5; Honeybee Venom; Wasp Venom; Double Positivity; Ige; Bee; Epidemiology; Relevant
ISSN (print) / ISBN
2213-2198
e-ISSN
2213-2201
Quellenangaben
Volume: 11,
Issue: 9,
Pages: 2890-2899.e2
Publisher
Elsevier
Publishing Place
Amsterdam [u.a.]
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Allergy Research (IAF)