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Singh, P.* ; Gollapalli, K.* ; Mangiola, S.* ; Schranner, D. ; Yusuf, M.A.* ; Chamoli, M.* ; Shi, S.L.* ; Lopes Bastos, B.* ; Nair, T.* ; Riermeier, A.* ; Vayndorf, E.M.* ; Wu, J.Z.* ; Nilakhe, A.* ; Nguyen, C.Q.* ; Muir, M.* ; Kiflezghi, M.G.* ; Foulger, A.* ; Junker, A.* ; Devine, J.* ; Sharan, K.* ; Chinta, S.J.* ; Rajput, S.* ; Rane, A.* ; Baumert, P.* ; Schönfelder, M.* ; Iavarone, F.* ; di Lorenzo, G.* ; Kumari, S.* ; Gupta, A.* ; Sakar, R.* ; Khyriem, C.* ; Chawla, A.S.* ; Sharma, A.* ; Sarper, N.* ; Chattopadhyay, N.* ; Biswal, B.K.* ; Settembre, C.* ; Nagarajan, P.* ; Targoff, K.L.* ; Picard, M.* ; Gupta, S.* ; Velagapudi, V.* ; Papenfuss, A.T.* ; Kaya, A.* ; Ferreira, M.G.* ; Kennedy, B.K.* ; Andersen, J.K.* ; Lithgow, G.J.* ; Ali, A.M.* ; Mukhopadhyay, A.* ; Palotie, A.* ; Kastenmüller, G. ; Kaeberlein, M.* ; Wackerhage, H.* ; Pal, B.* ; Yadav, V.K.*

Taurine deficiency as a driver of aging.

Science 380:eabn9257 (2023)
Postprint DOI PMC
Open Access Green
Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Amino-acid-concentrations; Stem-cells; Plasma; Pathways; Identification; Reproduction; Transporter; Metabolism; Regulators; Expression
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Journal Science
Quellenangaben Volume: 380, Issue: 6649, Pages: , Article Number: eabn9257 Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Publishing Place 1200 New York Ave, Nw, Washington, Dc 20005 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Computational Biology (ICB)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-503891-001
Grants Institut National Du Cancer (INCa)
Deutsche Forschungsgemeinschaft (DFG)
Wellcome
National Institutes of Health (NIH)
Nathan Shock Center of Excellence in the Basic Biology of Aging Project
Department of Biotechnology (DBT)
Science and Engineering Research Board (SERB)
Academy of Finland Center of Excellence in Complex Disease Genetics
Sigrid Juselius Foundation
Larry L. Hillblom Foundation Fellowship
Victorian Cancer Agency (VCA) Fellowship
DBT Ramalingaswamy Fellowship
Longevity Impetus Grant
DOI 10.1126/science.abn9257
WOS ID 001169190400002
WOS ID 001180485900001
Scopus ID 85163908065
PubMed ID 37289866
Erfassungsdatum 2023-10-06
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