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Schürfeld, R.* ; Sandner, B.* ; Hoffmann, A.* ; Klöting, N. ; Baratashvili, E.* ; Nowicki, M.* ; Paeschke, S.* ; Kosacka, J.* ; Kralisch, S.* ; Bachmann, A.* ; Frille, A.* ; Dietel, A.* ; Stolzenburg, J.U.* ; Blüher, M. ; Zhang, M.Z.* ; Harris, R.C.* ; Isermann, B.* ; Stumvoll, M.* ; Tönjes, A.* ; Ebert, T.*

Renal function is a major predictor of circulating acyl-CoA-binding protein/diazepam-binding inhibitor.

Front. Endocrin. 14:1152444 (2023)
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OBJECTIVE: Acyl-CoA-binding protein (ACBP)/diazepam-binding inhibitor has lately been described as an endocrine factor affecting food intake and lipid metabolism. ACBP is dysregulated in catabolic/malnutrition states like sepsis or systemic inflammation. However, regulation of ACBP has not been investigated in conditions with impaired kidney function, so far. DESIGN/METHODS: Serum ACBP concentrations were investigated by enzyme-linked immunosorbent assay i) in a cohort of 60 individuals with kidney failure (KF) on chronic haemodialysis and compared to 60 individuals with a preserved kidney function; and ii) in a human model of acute kidney dysfunction (AKD). In addition, mACBP mRNA expression was assessed in two CKD mouse models and in two distinct groups of non-CKD mice. Further, mRNA expression of mACBP was measured in vitro in isolated, differentiated mouse adipocytes - brown and white - after exposure to the uremic agent indoxyl sulfate. RESULTS: Median [interquartile range] serum ACBP was almost 20-fold increased in KF (514.0 [339.3] µg/l) compared to subjects without KF (26.1 [39.1] µg/l) (p<0.001). eGFR was the most important, inverse predictor of circulating ACBP in multivariate analysis (standardized β=-0.839; p<0.001). Furthermore, AKD increased ACBP concentrations almost 3-fold (p<0.001). Increased ACBP levels were not caused by augmented mACBP mRNA expression in different tissues of CKD mice in vivo or in indoxyl sulfate-treated adipocytes in vitro. CONCLUSIONS: Circulating ACBP inversely associates with renal function, most likely through renal retention of the cytokine. Future studies need to investigate ACBP physiology in malnutrition-related disease states, such as CKD, and to adjust for markers of renal function.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Acyl-coa-binding Protein ; Adipokines ; Chronic Kidney Disease ; Diabetic Kidney Disease ; Diazepam Binding Inhibitor ; Hemodialysis ; Type 2 Diabetes Mellitus; Kidney-disease; Interleukin-6; Progranulin; Expression; Glucose; Protein
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 1664-2392
e-ISSN 1664-2392
Journal Frontiers in Endocrinology
Quellenangaben Volume: 14, Issue: , Pages: , Article Number: 1152444 Supplement: ,
Publisher Frontiers
Publishing Place Lausanne
Reviewing status Peer reviewed
Institute(s) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-506500-001
G-506501-001
DOI 10.3389/fendo.2023.1152444
WOS ID 000999771600001
Scopus ID 85161013804
PubMed ID 37288304
Erfassungsdatum 2023-10-06
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