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Niedermayer, F. ; Su, Y. ; von Krüchten, R.* ; Thorand, B. ; Peters, A. ; Rathmann, W.* ; Roden, M.* ; Schlett, C.L.* ; Bamberg, F.* ; Nattenmüller, J.* ; Rospleszcz, S.

Trajectories of glycaemic traits exhibit sex-specific associations with hepatic iron and fat content: Results from the KORA-MRI study.

Liver Int. 43, 2153-2166 (2023)
DOI PMC
Creative Commons Lizenzvertrag
Open Access Green as soon as Postprint is submitted to ZB.
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) represents a major disease burden in the population. While the bidirectional association between NAFLD and diabetes is established, little is known about the association of hepatic iron content and glycaemia. Moreover, analyses of sex-specific effects and of dynamic changes in glycaemia are scarce. METHODS: We investigated 7-year sex-specific trajectories of glycaemia and related traits (HbA1c, fasting glucose, fasting insulin, HOMA-IR, 2-h glucose and cross-sectional 2-h insulin) in a sample from a population-based cohort (N = 365; 41.1% female). Hepatic iron and fat content were assessed by 3T-Magnetic Resonance Imaging (MRI). Two-step multi-level models adjusted for glucose-lowering medication and confounders were applied. RESULTS: In women and men, markers of glucose metabolism correlated with hepatic iron and fat content. Deterioration of glycaemia was associated with increased hepatic iron content in men (normoglycaemia to prediabetes: beta = 2.21 s-1 , 95% CI [0.47, 3.95]). Additionally, deterioration of glycaemia (e.g. prediabetes to diabetes: 1.27 log(%), [0.84, 1.70]) and trajectories of glucose, insulin and HOMA-IR were significantly associated with hepatic fat content in men. Similarly, deterioration of glycaemia as well as trajectories of glucose, insulin and HOMA-IR was significantly associated with increased hepatic fat content in women (e.g. trajectory of fasting insulin: 0.63 log(%), [0.36, 0.90]). CONCLUSIONS: Unfavourable 7-year trajectories of markers of glucose metabolism are associated with increased hepatic fat content, particularly in women, whereas the association with hepatic iron content was less clear. Monitoring changes of glycaemia in the sub-diabetic range might enable early identification of hepatic iron overload and steatosis.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Hba1c ; Nafld ; Diabetes ; Glucose ; Hepatic Fat ; Hepatic Iron ; Insulin ; Sex ; Trajectories; Population; Overload; Disease
ISSN (print) / ISBN 1478-3223
e-ISSN 1478-3231
Journal Liver International
Quellenangaben Volume: 43, Issue: 10, Pages: 2153-2166 Article Number: , Supplement: ,
Publisher Blackwell
Publishing Place Oxford
Non-patent literature Publications
Institute(s) Institute of Epidemiology II (EPI2)