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A resource of human coronavirus protein-coding sequences in a flexible, multipurpose Gateway Entry clone collection.
Genes Genomes Genetics G3 13:6 (2023)
The COVID-19 pandemic has catalyzed unprecedented scientific data and reagent sharing and collaboration, which enabled understanding the virology of the SARS-CoV-2 virus and vaccine development at record speed. The pandemic, however, has also raised awareness of the danger posed by the family of coronaviruses, of which 7 are known to infect humans and dozens have been identified in reservoir species, such as bats, rodents, or livestock. To facilitate understanding the commonalities and specifics of coronavirus infections and aspects of viral biology that determine their level of lethality to the human host, we have generated a collection of freely available clones encoding nearly all human coronavirus proteins known to date. We hope that this flexible, Gateway-compatible vector collection will encourage further research into the interactions of coronaviruses with their human host, to increase preparedness for future zoonotic viral outbreaks.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
229e ; Gateway Entry Clone ; Hcov ; Hku1 ; Mers ; Nl63 ; Oc43 ; Sars-cov-2 ; Coding Sequence ; Coronavirus; Sars
ISSN (print) / ISBN
2160-1836
e-ISSN
2160-1836
Journal
Genes Genomes Genetics G3
Quellenangaben
Volume: 13,
Issue: 7,
Article Number: 6
Publisher
Genetics Society of America
Publishing Place
Pittsburgh, PA
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Network Biology (INET)
Grants
Free State of Bavaria's AI for Therapy (AI4T) Initiative through the Institute of AI for Drug Discovery (AID)
European Union
European Union