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Kapellos, T. ; Baßler, K.* ; Fujii, W.* ; Nalkurthi, C.* ; Schaar, A. ; Bonaguro, L.* ; Pecht, T.* ; Galvao, I.* ; Agrawal, S.* ; Saglam, A.* ; Dudkin, E.* ; Frishberg, A. ; De Domenico, E.* ; Horne, A.* ; Donovan, C.* ; Kim, R.Y.* ; Gallego-Ortega, D.* ; Gillett, T.E.* ; Ansari, M. ; Schulte-Schrepping, J.* ; Offermann, N.* ; Antignano, I.* ; Sivri, B.* ; Lu, W.* ; Eapen, M.S.* ; van Uelft, M.* ; Osei-Sarpong, C.* ; van den Berge, M.* ; Donker, H.C.* ; Groen, H.J.M.* ; Sohal, S.S.* ; Klein, J.* ; Schreiber, T.* ; Feißt, A.* ; Yildirim, A.Ö. ; Schiller, H. ; Nawijn, M.C.* ; Becker, M.* ; Händler, K.* ; Beyer, M.* ; Capasso, M.* ; Ulas, T.* ; Hasenauer, J. ; Pizarro, C.* ; Theis, F.J. ; Hansbro, P.M.* ; Skowasch, D.* ; Schultze, J.

Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease.

Cell Rep. 42:112525 (2023)

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	Open Access Gold

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Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defined. Chronic obstructive pulmonary disease (COPD) is a major respiratory disease characterized by small-airway inflammation, emphysema, and severe breathing difficulties. Using single-cell analyses we demonstrate that blood neutrophils are already increased in early-stage COPD, and changes in molecular and functional neutrophil states correlate with lung function decline. Assessing neutrophils and their bone marrow precursors in a murine cigarette smoke exposure model identified similar molecular changes in blood neutrophils and precursor populations that also occur in the blood and lung. Our study shows that systemic molecular alterations in neutrophils and their precursors are part of early-stage COPD, a finding to be further explored for potential therapeutic targets and biomarkers for early diagnosis and patient stratification.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Cp: Immunology ; Blood ; Bone Marrow ; Chronic Obstructive Pulmonary Disease ; Granulopoiesis ; Neutrophil ; Single-cell Transcriptomics; R Package; Copd; Homeostasis; Population; Expression

ISSN (print) / ISBN 2211-1247

e-ISSN 2211-1247

Journal Cell Reports

Quellenangaben Volume: 42, Issue: 6, Article Number: 112525

Publisher Cell Press

Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Lung Health and Immunity (LHI)
Institute of Computational Biology (ICB)
Institute of Lung Biology (LHI)

Grants UTS
National Health and Medical Research Council (NHMRC) of Australia
Helmholtz Zukunftsthema Immunology and Inflammation
Clifford Craig Foundation Launceston General Hospital
Joint Programming Initiative, A Healthy Diet for a Healthy Life (JPI HDHL)
Helmholtz
Germany's Excellence Strategy
German Research Foundation)
Deutsche Forschungsgemeinschaft (DFG
EU
EU Horizon 2020 project SYSCID
BMBF
Alexander von Humboldt Foundation