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Magnussen, C.* ; Ojeda, F.M.* ; Leong, D.P.* ; Alegre-Diaz, J.* ; Amouyel, P.* ; Aviles-Santa, L.* ; de Bacquer, D.* ; Ballantyne, C.M.* ; Bernabe-Ortiz, A.* ; Bobak, M.* ; Brenner, H.* ; Carrillo-Larco, R.M.* ; de Lemos, J.* ; Dobson, A.* ; Dörr, M.* ; Donfrancesco, C.* ; Drygas, W.* ; Dullaart, R.P.* ; Engström, G.* ; Ferrario, M.M.* ; Ferrieres, J.* ; de Gaetano, G.* ; Goldbourt, U.* ; Gonzalez, C.* ; Grassi, G.* ; Hodge, A.M.* ; Hveem, K.* ; Iacoviello, L.* ; Ikram, M.K.* ; Irazola, V.* ; Jobe, M.* ; Jousilahti, P.* ; Kaleebu, P.* ; Kavousi, M.* ; Kee, F.* ; Khalili, D.* ; Koenig, W.* ; Kontsevaya, A.* ; Kuulasmaa, K.* ; Lackner, K.J.* ; Leistner, D.M.* ; Lind, L.* ; Linneberg, A.* ; Lorenz, T.* ; Lyngbakken, M.N.* ; Malekzadeh, R.* ; Malyutina, S.* ; Mathiesen, E.B.* ; Melander, O.* ; Metspalu, A.* ; Miranda, J.J.* ; Moitry, M.* ; Mugisha, J.* ; Nalini, M.* ; Nambi, V.* ; Ninomiya, T.* ; Oppermann, K.* ; d'Orsi, E.* ; Pajak, A.* ; Palmieri, L.* ; Panagiotakos, D.* ; Perianayagam, A.* ; Peters, A. ; Poustchi, H.* ; Prentice, A.M.* ; Prescott, E.* ; Risérus, U.* ; Salomaa, V.* ; Sans, S.* ; Sakata, S.* ; Schöttker, B.* ; Schutte, A.E.* ; Sepanlou, S.G.* ; Sharma, S.K.* ; Shaw, J.E.* ; Simons, L.A.* ; Söderberg, S.* ; Tamosiunas, A.* ; Thorand, B. ; Tunstall-Pedoe, H.* ; Twerenbold, R.* ; Vanuzzo, D.* ; Veronesi, G.* ; Waibel, J.* ; Wannamethee, S.G.* ; Watanabe, M.* ; Wild, P.S.* ; Yao, Y.* ; Zeng, Y.* ; Ziegler, A.* ; Blankenberg, S.*

Global effect of modifiable risk factors on cardiovascular disease and mortality.

N. Engl. J. Med. 389, 1273-1285 (2023)
Postprint DOI PMC
BACKGROUND: Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking. METHODS: We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality. RESULTS: Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6). CONCLUSIONS: Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.).
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Low-income Countries; Middle-income; Burden; Population; Troponin; Women; Men
ISSN (print) / ISBN 0028-4793
e-ISSN 1533-4406
Journal New England Journal of Medicine, The / NEJM
Quellenangaben Volume: 389, Issue: 14, Pages: 1273-1285 Article Number: , Supplement: ,
Publisher Massachusetts Medical Society (MMS)
Publishing Place Waltham Woods Center, 860 Winter St,, Waltham, Ma 02451-1413 Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology II (EPI2)
Grants German Center for Cardiovascular Research (DZHK)