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How european research projects can support vaccination strategies: The case of the ORCHESTRA project for SARS-CoV-2.
Vaccines 11:8 (2023)
ORCHESTRA ("Connecting European Cohorts to Increase Common and Effective Response To SARS-CoV-2 Pandemic") is an EU-funded project which aims to help rapidly advance the knowledge related to the prevention of the SARS-CoV-2 infection and the management of COVID-19 and its long-term sequelae. Here, we describe the early results of this project, focusing on the strengths of multiple, international, historical and prospective cohort studies and highlighting those results which are of potential relevance for vaccination strategies, such as the necessity of a vaccine booster dose after a primary vaccination course in hematologic cancer patients and in solid organ transplant recipients to elicit a higher antibody titer, and the protective effect of vaccination on severe COVID-19 clinical manifestation and on the emergence of post-COVID-19 conditions. Valuable data regarding epidemiological variations, risk factors of SARS-CoV-2 infection and its sequelae, and vaccination efficacy in different subpopulations can support further defining public health vaccination policies.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Covid-19 ; Cohort Study ; Data Harmonization ; Fragile Population ; Healthcare Workers ; Public Health ; Vaccination
e-ISSN
2076-393X
Journal
Vaccines
Quellenangaben
Volume: 11,
Issue: 8
Article Number: 8
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Computational Biology (ICB)
Grants
European Union