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Lendner, J.D.* ; Niethard, N.* ; Mander, B.A.* ; van Schalkwijk, F.J.* ; Schuh-Hofer, S.* ; Schmidt, H.* ; Knight, R.T.* ; Born, J. ; Walker, M.P.* ; Lin, J.J.* ; Helfrich, R.F.*

Human REM sleep recalibrates neural activity in support of memory formation.

Sci. Adv. 9:eadj1895 (2023)
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The proposed mechanisms of sleep-dependent memory consolidation involve the overnight regulation of neural activity at both synaptic and whole-network levels. Now, there is a lack of in vivo data in humans elucidating if, and how, sleep and its varied stages balance neural activity, and if such recalibration benefits memory. We combined electrophysiology with in vivo two-photon calcium imaging in rodents as well as intracranial and scalp electroencephalography (EEG) in humans to reveal a key role for non-oscillatory brain activity during rapid eye movement (REM) sleep to mediate sleep-dependent recalibration of neural population dynamics. The extent of this REM sleep recalibration predicted the success of overnight memory consolidation, expressly the modulation of hippocampal-neocortical activity, favoring remembering rather than forgetting. The findings describe a non-oscillatory mechanism how human REM sleep modulates neural population activity to enhance long-term memory.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cortical Excitability; Eeg-data; Hippocampal; Oscillations; Deprivation; Inhibition; Plasticity; Awake; Potentiation; Homeostasis
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 2375-2548
e-ISSN 2375-2548
Journal Science Advances
Quellenangaben Volume: 9, Issue: 34, Pages: , Article Number: eadj1895 Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Publishing Place Washington, DC [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502400-001
Grants
National Institutes of Health
Network for Excellence in Clinical Neuroscience
Hertie Foundation
European Research Council
Emmy Noether Program
German Research Foundation
DOI 10.1126/sciadv.adj1895
WOS ID 001054596800010
Scopus ID 85168719479
PubMed ID 37624898
Erfassungsdatum 2023-10-06
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