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Matek, C. ; Marr, C. ; von Bergwelt-Baildon, M.* ; Spiekermann, K.*

Künstliche Intelligenz für die computerunterstützte Leukämiediagnostik.

Artificial Intelligence for computer-aided leukemia diagnostics.

Dtsch. Med. Wochenschr. 148, 1108-1112 (2023)
DOI PMC
The manual examination of blood and bone marrow specimens for leukemia patients is time-consuming and limited by intra- and inter-observer variance. The development of AI algorithms for leukemia diagnostics requires high-quality sample digitization and reliable annotation of large datasets. Deep learning-based algorithms using these datasets attain human-level performance for some well-defined, clinically relevant questions such as the blast character of cells. Methods such as multiple - instance - learning allow predicting diagnoses from a collection of leukocytes, but are more data-intensive. Using "explainable AI" methods can make the prediction process more transparent and allow users to verify the algorithm's predictions. Stability and robustness analyses are necessary for routine application of these algorithms, and regulatory institutions are developing standards for this purpose. Integrated diagnostics, which link different diagnostic modalities, offer the promise of even greater accuracy but require more extensive and diverse datasets.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Ai In Medical Image Analysis ; Computer-aided Diagnostics ; Cytomorphology ; Leukemia Diagnostics
ISSN (print) / ISBN 0012-0472
e-ISSN 1439-4413
Quellenangaben Volume: 148, Issue: 17, Pages: 1108-1112 Article Number: , Supplement: ,
Publisher Thieme
Publishing Place Rudigerstr 14, D-70469 Stuttgart, Germany
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of AI for Health (AIH)