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Garger, D. ; Meinel, M. ; Dietl, T. ; Hillig, C. ; Garzorz-Stark, N.* ; Eyerich, K.* ; Hrabě de Angelis, M. ; Eyerich, S. ; Menden, M.P.

The impact of the cardiovascular component and somatic mutations on ageing.

Aging Cell 22:e13957 (2023)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Mechanistic insight into ageing may empower prolonging the lifespan of humans; however, a complete understanding of this process is still lacking despite a plethora of ageing theories. In order to address this, we investigated the association of lifespan with eight phenotypic traits, that is, litter size, body mass, female and male sexual maturity, somatic mutation, heart, respiratory, and metabolic rate. In support of the somatic mutation theory, we analysed 15 mammalian species and their whole-genome sequencing deriving somatic mutation rate, which displayed the strongest negative correlation with lifespan. All remaining phenotypic traits showed almost equivalent strong associations across this mammalian cohort, however, resting heart rate explained additional variance in lifespan. Integrating somatic mutation and resting heart rate boosted the prediction of lifespan, thus highlighting that resting heart rate may either directly influence lifespan, or represents an epiphenomenon for additional lower-level mechanisms, for example, metabolic rate, that are associated with lifespan.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Aging ; Animals ; Biology ; Biostatistics ; Female ; Humans ; Litter Size ; Longevity ; Male ; Mammals ; Mutation ; Phenotype; Heart-rate-variability; Metabolic-rate; Life-span; Phylogenetic Signal; Body-size; Atherosclerosis; Determinants; Mechanisms; Rates; Time
ISSN (print) / ISBN 1474-9718
e-ISSN 1474-9726
Journal Aging Cell
Quellenangaben Volume: 22, Issue: 10, Pages: , Article Number: e13957 Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Computational Biology (ICB)
Institute of Experimental Genetics (IEG)
Institute for Allergy Research (IAF)
Grants European Research Council (ERC)
Helmholtz Association under the joint research school "Munich School for Data Science -MUDS"
European Union