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Open Access Green as soon as Postprint is submitted to ZB.
Insulin resistance is associated with the capillary permeability of thigh muscles in patients with type 2 diabetes.
J. Clin. Endocrinol. Metab. 109, e137-e144 (2023)
OBJECTIVE: Insulin-mediated microvascular permeability and blood flow of skeletal muscle appears to be altered in the condition of insulin resistance. Previous studies on this effect used invasive procedures in humans or animals. The aim of this study was to demonstrate the feasibility of a non-invasive assessment of human muscles' microcirculation via dynamic contrast-enhanced (DCE)-MRI of skeletal muscle in patients with type two diabetes (T2D). METHODS: 56 participants (46 with T2D, 10 healthy controls, HC) underwent DCE-MRI of the right thigh at 3 Tesla. The constant of the musculature's microvascular permeability (Ktrans), extravascular extracellular volume fraction (ve), and plasma volume fraction (vp) were calculated. RESULTS: In T2D patients, skeletal muscle Ktrans was lower (HC 0.0677 ± 0.002 min-1, T2D 0.0664 ± 0.002 min-1; p = 0.042) while the homeostasis model assessment (HOMA)-index was higher in patients with T2D compared to HC (HC 2.72 ± 2.2, T2D 6.11 ± 6.2; p = 0.011). In T2D, Ktrans correlated negatively with insulin (r = -0.39, p = 0.018) and HOMA-index (r = -0.38, p = 0.020). CONCLUSION: The results signify that skeletal muscle DCE MRI can be employed as a non-invasive technique for the assessment of muscles' microcirculation in T2D. Our findings suggest that microvascular permeability of skeletal muscle is lowered in patients with T2D and that a decrease in microvascular permeability is associated with insulin resistance. These results are of interest with regards to the impact of muscle perfusion on diabetic complications such as diabetic sarcopenia.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Diabetic Sarcopenia ; Dynamic Contrast Enhanced Mri ; Mr Myography ; Muscle Mri ; Muscle Perfusion ; Perfusion Mri; Human Skeletal-muscle; Microvascular Permeability; Surface-area; Blood-flow; Perfusion; Glucose; Macromolecules; Extravasation; Mellitus; Density
ISSN (print) / ISBN
0021-972X
e-ISSN
1945-7197
Quellenangaben
Volume: 109,
Issue: 1,
Pages: e137-e144
Publisher
Endocrine Society
Publishing Place
Bethesda, Md.
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)
Grants
German Research Council (DFG)
Novo Nordisk
Codman
Guerbet
Bayer
Novartis
Siemens
Else Kroner-Fresenius-Stiftung (EKFS)
Novo Nordisk
Codman
Guerbet
Bayer
Novartis
Siemens
Else Kroner-Fresenius-Stiftung (EKFS)