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Kolabas, Z.I. ; Kuemmerle, L. ; Perneczky, R.* ; Förstera, B. ; Ulukaya, S. ; Ali, M. ; Kapoor, S. ; Bartos, L.M.* ; Büttner, M. ; Caliskan, Ö.S. ; Rong, Z. ; Mai, H. ; Höher, L. ; Jeridi, D. ; Molbay, M. ; Khalin, I.* ; Deligiannis, I.K. ; Negwer, M. ; Roberts, K.* ; Simats, A.* ; Carofiglio, O.* ; Todorov, M.I. ; Horvath, I. ; Öztürk, F. ; Hummel, S.* ; Biechele, G.* ; Zatcepin, A.* ; Unterrainer, M.* ; Gnörich, J.* ; Roodselaar, J.* ; Shrouder, J.* ; Khosravani, P.* ; Tast, B.* ; Richter, L.* ; Díaz-Marugán, L.* ; Kaltenecker, D. ; Lux, L. ; Chen, Y.* ; Zhao, S. ; Rauchmann, B.S.* ; Sterr, M. ; Kunze, I. ; Stanic Aguilera, K.N. ; Kan, V.W.Y.* ; Besson-Girard, S.* ; Katzdobler, S.* ; Palleis, C.* ; Schädler, J.* ; Paetzold, J.C. ; Liebscher, S.* ; Hauser, A.E.* ; Gokce, O.* ; Lickert, H. ; Steinke, H.* ; Benakis, C.* ; Braun, C.* ; Martinez Jimenez, C.P. ; Buerger, K.* ; Albert, N.L.* ; Höglinger, G.* ; Levin, J.* ; Haass, C.* ; Kopczak, A.* ; Dichgans, M.* ; Havla, J.* ; Kümpfel, T.* ; Kerschensteiner, M.* ; Schifferer, M.* ; Simons, M.* ; Liesz, A.* ; Krahmer, N. ; Bayraktar, O.A.* ; Franzmeier, N.* ; Plesnila, N.* ; Erener, S. ; Puelles, V.G.* ; Delbridge, C.* ; Bhatia, H.S. ; Hellal, F. ; Elsner, M. ; Bechmann, I.* ; Ondruschka, B.* ; Brendel, M.* ; Theis, F.J. ; Ertürk, A.

Distinct molecular profiles of skull bone marrow in health and neurological disorders.

Cell 186, 3706-3725.e29 (2023)
Publ. Version/Full Text DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
The bone marrow in the skull is important for shaping immune responses in the brain and meninges, but its molecular makeup among bones and relevance in human diseases remain unclear. Here, we show that the mouse skull has the most distinct transcriptomic profile compared with other bones in states of health and injury, characterized by a late-stage neutrophil phenotype. In humans, proteome analysis reveals that the skull marrow is the most distinct, with differentially expressed neutrophil-related pathways and a unique synaptic protein signature. 3D imaging demonstrates the structural and cellular details of human skull-meninges connections (SMCs) compared with veins. Last, using translocator protein positron emission tomography (TSPO-PET) imaging, we show that the skull bone marrow reflects inflammatory brain responses with a disease-specific spatial distribution in patients with various neurological disorders. The unique molecular profile and anatomical and functional connections of the skull show its potential as a site for diagnosing, monitoring, and treating brain diseases.
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Publication type Article: Journal article
Document type Scientific Article
Keywords 3d-imaging ; Disco Clearing ; Pet Imaging ; Immune Cell Trafficking ; Neuroinflammation ; Neurological Disorders ; Non-invasive Monitoring ; Proteomics ; Scrna-seq ; Skull-brain Connection; Enrichment Analysis; Ischemic-stroke; Web Server; Reveals; Brain; Activation; Protein; Cells; Pet; Deposition
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 0092-8674
e-ISSN 1097-4172
Journal Cell
Quellenangaben Volume: 186, Issue: 17, Pages: 3706-3725.e29 Article Number: , Supplement: ,
Publisher Cell Press
Publishing Place Cambridge, Mass.
Reviewing status Peer reviewed
Institute(s) Institute for Tissue Engineering and Regenerative Medicine (ITERM)
Institute of Computational Biology (ICB)
Institute of Diabetes and Obesity (IDO)
Helmholtz Pioneer Campus (HPC)
Institute of Diabetes and Cancer (IDC)
Institute of Diabetes and Regeneration Research (IDR)
Institute of Stem Cell Research (ISF)
POF-Topic(s) 30205 - Bioengineering and Digital Health
90000 - German Center for Diabetes Research
30204 - Cell Programming and Repair
30201 - Metabolic Health
Research field(s) Enabling and Novel Technologies
Helmholtz Diabetes Center
Pioneer Campus
Stem Cell and Neuroscience
PSP Element(s) G-505800-001
G-503800-001
G-501900-221
G-510005-001
G-501900-253
G-501900-231
G-502300-001
G-500800-001
Grants Nomis Foundation
Vascular Dementia Research Foundation
Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
Friedrich-Baur-Stiftung
Luneburg Heritage Foundation
European Research Council (ERC)
Einstein Foundation Berlin
Novo Nordisk Foundation
National Institute for Health and Care Research (NIHR) Sheffield Biomedical Research Centre
Hirnliga e.V
Alzheimer Forschung Initiative
BMBF
NATON collaboration of the Network University Medicine
EMed Consortia "Fibromap."
DOI 10.1016/j.cell.2023.07.009
WOS ID 001145023000001
Scopus ID 85167792491
PubMed ID 37562402
Erfassungsdatum 2023-10-06
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