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Demir, M.* ; Bornstein, S.R. ; Mantzoros, C.S.* ; Perakakis, N.

Liver fat as risk factor of hepatic and cardiometabolic diseases.

Obes. Rev. 24:e13612 (2023)
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Non-alcoholic fatty liver disease (NAFLD) is a disorder characterized by excessive accumulation of fat in the liver that can progress to liver inflammation (non-alcoholic steatohepatitis [NASH]), liver fibrosis, and cirrhosis. Although most efforts for drug development are focusing on the treatment of the latest stages of NAFLD, where significant fibrosis and NASH are present, findings from studies suggest that the amount of liver fat may be an important independent risk factor and/or predictor of development and progression of NAFLD and metabolic diseases. In this review, we first describe the current tools available for quantification of liver fat in humans and then present the clinical and pathophysiological evidence that link liver fat with NAFLD progression as well as with cardiometabolic diseases. Finally, we discuss current pharmacological and non-pharmacological approaches to reduce liver fat and present open questions that have to be addressed in future studies.
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Publication type Article: Journal article
Document type Review
Keywords Cardiovascular ; Diabetes ; Obesity ; Steatosis; Controlled Attenuation Parameter; Exome-wide Association; Nonalcoholic Steatohepatitis; Insulin-resistance; Diagnostic-accuracy; External Validation; Triglyceride Levels; Bariatric Surgery; Total Cholesterol; Weight-loss
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 1467-7881
e-ISSN 1467-789X
Journal Obesity Reviews
Quellenangaben Volume: 24, Issue: 10, Pages: , Article Number: e13612 Supplement: ,
Publisher Blackwell
Publishing Place Oxford
Reviewing status Peer reviewed
Institute(s) Institute of Pancreatic Islet Research (IPI)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502600-012
G-502600-007
Grants Deutsche Forschungsgemeinschaft
Bundesministerium fuer Bildung und Forschung
DOI 10.1111/obr.13612
WOS ID 001044110500001
Scopus ID 85166939208
PubMed ID 37553237
Erfassungsdatum 2023-10-06
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