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Liver fat as risk factor of hepatic and cardiometabolic diseases.
Obes. Rev. 24:e13612 (2023)
Non-alcoholic fatty liver disease (NAFLD) is a disorder characterized by excessive accumulation of fat in the liver that can progress to liver inflammation (non-alcoholic steatohepatitis [NASH]), liver fibrosis, and cirrhosis. Although most efforts for drug development are focusing on the treatment of the latest stages of NAFLD, where significant fibrosis and NASH are present, findings from studies suggest that the amount of liver fat may be an important independent risk factor and/or predictor of development and progression of NAFLD and metabolic diseases. In this review, we first describe the current tools available for quantification of liver fat in humans and then present the clinical and pathophysiological evidence that link liver fat with NAFLD progression as well as with cardiometabolic diseases. Finally, we discuss current pharmacological and non-pharmacological approaches to reduce liver fat and present open questions that have to be addressed in future studies.
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Publication type
Article: Journal article
Document type
Review
Keywords
Cardiovascular ; Diabetes ; Obesity ; Steatosis; Controlled Attenuation Parameter; Exome-wide Association; Nonalcoholic Steatohepatitis; Insulin-resistance; Diagnostic-accuracy; External Validation; Triglyceride Levels; Bariatric Surgery; Total Cholesterol; Weight-loss
ISSN (print) / ISBN
1467-7881
e-ISSN
1467-789X
Journal
Obesity Reviews
Quellenangaben
Volume: 24,
Issue: 10,
Article Number: e13612
Publisher
Blackwell
Publishing Place
Oxford
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Pancreatic Beta Cell Research (IPI)
Grants
Deutsche Forschungsgemeinschaft
Bundesministerium fuer Bildung und Forschung
Bundesministerium fuer Bildung und Forschung