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Open Access Green as soon as Postprint is submitted to ZB.
The therapeutic potential of targeting regulated non-apoptotic cell death.
Nat. Rev. Drug Discov. 22, 723-742 (2023)
Cell death is critical for the development and homeostasis of almost all multicellular organisms. Moreover, its dysregulation leads to diverse disease states. Historically, apoptosis was thought to be the major regulated cell death pathway, whereas necrosis was considered to be an unregulated form of cell death. However, research in recent decades has uncovered several forms of regulated necrosis that are implicated in degenerative diseases, inflammatory conditions and cancer. The growing insight into these regulated, non-apoptotic cell death pathways has opened new avenues for therapeutic targeting. Here, we describe the regulatory pathways of necroptosis, pyroptosis, parthanatos, ferroptosis, cuproptosis, lysozincrosis and disulfidptosis. We discuss small-molecule inhibitors of the pathways and prospects for future drug discovery. Together, the complex mechanisms governing these pathways offer strategies to develop therapeutics that control non-apoptotic cell death.
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Publication type
Article: Journal article
Document type
Review
Keywords
Mixed Lineage Kinase; Poly(adp-ribose) Par Polymer; Interacting Protein-1 Rip1; Glutathione-peroxidase 4; Gamma-inducing Factor; Highly Potent; Nlrp3 Inflammasome; Domain-like; Lipid-peroxidation; Cognitive Impairment
ISSN (print) / ISBN
1474-1776
Journal
Nature Reviews - Drug Discovery
Quellenangaben
Volume: 22,
Issue: 9,
Pages: 723-742
Publisher
Nature Publishing Group
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Signaling and Translation (SAT)
Grants
NINDS
NCI grant
NCI grant