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Open Access Green as soon as Postprint is submitted to ZB.
Short-term western diet causes rapid and lasting alterations of bone marrow physiology.
Thromb. Haemost. 123, 1100-1104 (2023)
Dietary factors have a significant impact on overall health and western diet (WD) disrupts arterial homeostasis, thereby promoting atherosclerosis. In our study, we investigated the effects of short-term WD on bone marrow vasculature and hematopoiesis in hypercholesterolemic mice. We found that WD rapidly remodels bone marrow arterioles, and these alterations persist even after WD cessation. The proximity between hematopoietic stem cells (HSCs) and arterioles increased with short-term WD, which was associated with a reduced HSC counts as well as an increased number of progenitor cells and a higher production of myeloid cells. Additionally, the remaining HSCs showed increased proliferation, potentially raising susceptibility to clonal hematopoiesis. Collectively, our findings show that short-term WD dramatically alters the bone marrow physiology with lasting consequences.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Bone Marrow Vessels ; Clonal Hematopoiesis ; Hematopoietic Stem Cells ; Western Diet; Hematopoietic Stem-cells; Clonal Hematopoiesis; Niches; Reveal
ISSN (print) / ISBN
0340-6245
Journal
Thrombosis and Haemostasis
Quellenangaben
Volume: 123,
Issue: 11,
Pages: 1100-1104
Publisher
Schattauer
Publishing Place
Rudigerstr 14, D-70469 Stuttgart, Germany
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Medicine (IRM)
Grants
Deutsche Forschungsgemeinschaft