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Colombo, S.A.P.* ; Brown, S.L.* ; Hepworth, M.R.* ; Hankinson, J. ; Granato, F.* ; Kitchen, S.J.* ; Hussell, T.* ; Simpson, A.* ; Cook, P.C.* ; MacDonald, A.S.*

Comparative phenotype of circulating versus tissue immune cells in human lung and blood compartments during health and disease.

Discov. Immunol. 2:kyad009 (2023)

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The lung is a dynamic mucosal surface constantly exposed to a variety of immunological challenges including harmless environmental antigens, pollutants, and potentially invasive microorganisms. Dysregulation of the immune system at this crucial site is associated with a range of chronic inflammatory conditions including asthma and Chronic Pulmonary Obstructive Disease (COPD). However, due to its relative inaccessibility, our fundamental understanding of the human lung immune compartment is limited. To address this, we performed flow cytometric immune phenotyping of human lung tissue and matched blood samples that were isolated from 115 donors undergoing lung tissue resection. We provide detailed characterization of the lung mononuclear phagocyte and T cell compartments, demonstrating clear phenotypic differences between lung tissue cells and those in peripheral circulation. Additionally, we show that CD103 expression demarcates pulmonary T cells that have undergone recent TCR and IL-7R signalling. Unexpectedly, we discovered that the immune landscape from asthmatic or COPD donors was broadly comparable to controls. Our data provide a much-needed expansion of our understanding of the pulmonary immune compartment in both health and disease.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Copd ; T Cells ; Asthma ; Dendritic Cells ; Mucosal Immunology

ISSN (print) / ISBN 2754-2483

e-ISSN 2754-2483

Journal Discovery immunology

Quellenangaben Volume: 2, Issue: 1, Article Number: kyad009

Publisher Oxford University Press

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Translational Genomics (ITG)