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Xiong, Y.* ; Feng, Q.* ; Lu, L.* ; Qiu, X.* ; Knoedler, S. ; Panayi, A.C.* ; Jiang, D. ; Rinkevich, Y. ; Lin, Z.* ; Mi, B.* ; Liu, G.* ; Zhao, Y.*

Metal-organic frameworks and their composites for chronic wound healing: From bench to bedside.

Adv. Mater. 36:e2302587 (2023)
Publ. Version/Full Text DOI PMC
Chronic wounds are characterized by delayed and dysregulated healing processes. As such, they have emerged as an increasingly significant threat. The associated morbidity and socioeconomic toll are clinically and financially challenging, necessitating novel approaches in the management of chronic wounds. Metal-organic frameworks (MOFs) are an innovative type of porous coordination polymers, with low toxicity and high eco-friendliness. Documented anti-bacterial effects and pro-angiogenic activity predestine these nanomaterials as promising systems for the treatment of chronic wounds. In this context, the therapeutic applicability and efficacy of MOFs remain to be elucidated. We, therefore, review structural-functional properties of MOFs and their composite materials and discuss how their multifunctionality and customizability could be leveraged as a clinical therapy for chronic wounds. This article is protected by copyright. All rights reserved.
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Publication type Article: Journal article
Document type Review
Keywords Biomaterials ; Chronic Wounds ; Metal-organic Frameworks ; Multifunctionality ; Nanomedicine; Tissue-repair; Bacteria; Nanoparticles; Regeneration; Hydrogels; Release; Acid
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 0935-9648
e-ISSN 1521-4095
Journal Advanced materials
Quellenangaben Volume: 36, Issue: 2, Pages: , Article Number: e2302587 Supplement: ,
Publisher Wiley
Publishing Place Weinheim
Reviewing status Peer reviewed
Institute(s) Institute of Regenerative Biology and Medicine (IRBM)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-509400-001
Grants European Union
German Research Foundation
China Postdoctoral Science Foundation
Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration
National Science Foundation of China
Y.X. and Q.F. contributed equally to this work. This work was supported by the National Science Foundation of China (No. 82002313, 82072444, 31900963, and 82202714), the Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration
DOI 10.1002/adma.202302587
WOS ID 001096889600001
Scopus ID 85175992710
PubMed ID 37527058
Erfassungsdatum 2023-10-06
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