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Perakakis, N. ; Harb, H.* ; Hale, B.G.* ; Varga, Z.* ; Steenblock, C.* ; Kanczkowski, W.* ; Alexaki, V.I.* ; Ludwig, B. ; Mirtschink, P.* ; Solimena, M. ; Toepfner, N.* ; Zeissig, S.* ; Gado, M. ; Abela, I.A.* ; Beuschlein, F.* ; Spinas, G.A.* ; Cavelti-Weder, C.* ; Gerber, P.A.* ; Huber, M.* ; Trkola, A.* ; Puhan, M.A.* ; Wong, W.W.* ; Linkermann, A.* ; Mohan, V.* ; Lehnert, H.* ; Nawroth, P.* ; Chavakis, T. ; Mingrone, G.* ; Wolfrum, C.* ; Zinkernagel, A.S.* ; Bornstein, S.R.

Mechanisms and clinical relevance of the bidirectional relationship of viral infections with metabolic diseases.

Lancet Diabet. Endocrinol. 11, 675-693 (2023)
Postprint DOI PMC
Open Access Green
Viruses have been present during all evolutionary steps on earth and have had a major effect on human history. Viral infections are still among the leading causes of death. Another public health concern is the increase of non-communicable metabolic diseases in the last four decades. In this Review, we revisit the scientific evidence supporting the presence of a strong bidirectional feedback loop between several viral infections and metabolic diseases. We discuss how viruses might lead to the development or progression of metabolic diseases and conversely, how metabolic diseases might increase the severity of a viral infection. Furthermore, we discuss the clinical relevance of the current evidence on the relationship between viral infections and metabolic disease and the present and future challenges that should be addressed by the scientific community and health authorities.
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Publication type Article: Journal article
Document type Review
Keywords Hepatitis-c Virus; Type-1 Diabetes-mellitus; Fatty Liver-disease; Risk-factors; Enterovirus Infection; Insulin-resistance; Sars-cov-2 Infection; Virological Response; Nondiabetic Patients; Coxsackievirus B1
ISSN (print) / ISBN 2213-8587
e-ISSN 2213-8595
Journal Lancet Diabetes and Endocrinology
Quellenangaben Volume: 11, Issue: 9, Pages: 675-693 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Ste 800, 230 Park Ave, New York, Ny 10169 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Pancreatic Islet Research (IPI)
Grants Swiss Nat Foundation
Promedica foundation
Deutsche Forschungsgemeinschaft
LOOP Zurich Medical Research Center
Bundesministerium fur Bildung und Forschung-Deutsches Zentrum fuer Diabetesforschung