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Open Access Green as soon as Postprint is submitted to ZB.
Circadian expression of steroidogenic cytochromes P450 in the mouse adrenal gland - involvement of cAMP-responsive element modulator in epigenetic regulation of Cyp17a1.
FEBS J. 279, 1584-1593 (2012)
The cytochrome P450 (CYP) genes Cyp51, Cyp11a1, Cyp17a1, Cyb11b1, Cyp11b2 and Cyp21a1 are involved in the adrenal production of corticosteroids, whose circulating levels are circadian. cAMP signaling plays an important role in adrenal steroidogenesis. By using cAMP responsive element modulator (Crem) knockout mice, we show that CREM isoforms contribute to circadian expression of steroidogenic CYPs in the mouse adrenal gland. Most striking was the CREM-dependent hypomethylation of the Cyp17a1 promoter at zeitgeber time 12, which resulted in higher Cyp17a1 mRNA and protein expression in the knockout adrenal glands. The data indicate that products of the Crem gene control the epigenetic repression of Cyp17 in mouse adrenal glands.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
cAMP-responsive element modulator (CREM); circadian; corticosterone; CYP17A1; DNA methylation
ISSN (print) / ISBN
1742-464X
e-ISSN
1742-4658
Journal
FEBS Journal, The
Quellenangaben
Volume: 279,
Issue: 9,
Pages: 1584-1593
Publisher
Wiley
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Molekulare Endokrinologie und Metabolismus (MEM)