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Human serum albumin-bound selenium (Se-HSA) in serum and its correlation with other selenium species.
J. Trace Elem. Med. Biol. 79:127266 (2023)
INTRODUCTION: Selenium (Se) is a trace element with different toxicological and nutritional properties according to its chemical forms. Among the wide range of selenium species, human serum albumin-bound selenium (Se-HSA) has still uncertain composition in terms of organic or inorganic selenium species. This study aimed at investigating the relation between Se-HSA levels with total selenium and the specific organic and inorganic selenium species. METHODS: We determined levels of total selenium and selenium species in serum of participants enrolled in two populations of the Emilia-Romagna region, in Northern Italy. Anion exchange chromatography coupled with inductively coupled plasma dynamic reaction cell mass spectrometry was used as quantification method. Correlations between Se-HSA and the other selenium compounds were analyzed using linear regression and restricted cubic spline regression models, adjusted for potential confounders. RESULTS: The first cohort comprised 50 participants (men/women: 26/24) with median (interquartile range, IQR) age 50 (55-62) years, while the second was composed of 104 participants (M/W: 50/54), median (IQR) age 48 (44-53) years. Median (IQR) levels of total selenium were 118.5 (109-136) µg/L and 116.5 (106-128) µg/L, respectively, while Se-HSA was 25.5 µg/L (16.2-51.5) and 1.1 (0.03-3.1) µg/L, respectively. In both populations, Se-HSA was positively associated with inorganic selenium species. Conversely, Se-HSA was inversely associated with organic selenium, especially with selenoprotein P-bound-Se (Se-SELENOP) and less strongly with selenomethionine-bound-Se (Se-Met), while the relation was null or even positive with other organic species. Evaluation of non-linear trends showed a substantially positive association with inorganic selenium, particularly selenite, until a concentration of 30 µg/L, above which a plateau was reached. The association with Se-SELENOP was inverse and strong until 100 µg/L, while it was almost null at higher levels. CONCLUSIONS: Our findings seem to indicate that Se-HSA incorporates more selenium when circulating levels of inorganic compounds are higher, thus supporting its mainly inorganic nature, particularly at high circulating levels of selenite.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Epidemiology ; Se-hsa ; Selenium ; Selenoprotein P ; Serum Albumin ; Speciation; Cerebrospinal-fluid; Stable-isotope; Speciation; Selenoproteins; Selenomethionine; Metabolism; Absorption; Proteins; Binding
ISSN (print) / ISBN
0946-672X
e-ISSN
1878-3252
Quellenangaben
Volume: 79,
Article Number: 127266
Publisher
Urban & Fischer
Publishing Place
Hackerbrucke 6, 80335 Munich, Germany
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Analytical BioGeoChemistry (BGC)
Grants
Local Health Authority of Reggio Emilia
Fondazione Pietro Manodori' of Reggio Emilia
Fondazione di Modena
University of Modena and Reggio Emilia
Italian Ministry of Education, University and Research
Dipartimenti di Eccellenza'
Fondazione Pietro Manodori' of Reggio Emilia
Fondazione di Modena
University of Modena and Reggio Emilia
Italian Ministry of Education, University and Research
Dipartimenti di Eccellenza'