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Miyakoshi, L.M.* ; Stæger, F.F.* ; Li, Q.* ; Pan, C. ; Xie, L.* ; Kang, H.* ; Pavan, C.* ; Dang, J.* ; Sun, Q.* ; Ertürk, A. ; Nedergaard, M.*

The state of brain activity modulates cerebrospinal fluid transport.

Prog. Neurobiol. 229:102512 (2023)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Earlier studies based on 2-photon imaging have shown that glymphatic cerebrospinal fluid (CSF) transport is regulated by the sleep-wake cycle. To examine this association, we used 3DISCO whole-body tissue clearing to map CSF tracer distribution in awake, sleeping and ketamine-xylazine anesthetized mice. The results of our analysis showed that CSF tracers entered the brain to a significantly larger extent in natural sleep or ketamine-xylazine anesthesia than in wakefulness. Furthermore, awake mice showed preferential transport of CSF tracers in the rostro-caudal direction towards the cervical and spinal cord lymphatic vessels, and hence to venous circulation and excretion by the kidneys. The study extends the current literature by showing that CSF dynamics on the whole-body scale is controlled by the state of brain activity.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cerebrospinal Fluid ; Neurodegeneration ; Neuromodulators ; Perivascular Spaces ; Sleep ; Tissue Clearance; Meningeal Lymphatic Drainage; Extracellular-space; Glymphatic System; Sleep Quality; Pathology; Clearance; Disease; Organs; Mice
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 0301-0082
e-ISSN 1873-5118
Journal Progress in Neurobiology
Quellenangaben Volume: 229, Issue: , Pages: , Article Number: 102512 Supplement: ,
Publisher Elsevier
Publishing Place The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
Reviewing status Peer reviewed
Institute(s) Institute for Tissue Engineering and Regenerative Medicine (ITERM)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505800-001
Grants Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
JPND Program
Simons Foundation
Human Frontier Science Program
US Army Research Office
National Institutes of Health
Novo Nordisk Foundation
Lundbeck Foundation
DOI 10.1016/j.pneurobio.2023.102512
WOS ID 001051955500001
Scopus ID 85166213773
PubMed ID 37482196
Erfassungsdatum 2023-10-06
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