Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
DOI
PMC
 |
|
Open Access Green as soon as Postprint is submitted to ZB.
The state of brain activity modulates cerebrospinal fluid transport.
Prog. Neurobiol. 229:102512 (2023)
Earlier studies based on 2-photon imaging have shown that glymphatic cerebrospinal fluid (CSF) transport is regulated by the sleep-wake cycle. To examine this association, we used 3DISCO whole-body tissue clearing to map CSF tracer distribution in awake, sleeping and ketamine-xylazine anesthetized mice. The results of our analysis showed that CSF tracers entered the brain to a significantly larger extent in natural sleep or ketamine-xylazine anesthesia than in wakefulness. Furthermore, awake mice showed preferential transport of CSF tracers in the rostro-caudal direction towards the cervical and spinal cord lymphatic vessels, and hence to venous circulation and excretion by the kidneys. The study extends the current literature by showing that CSF dynamics on the whole-body scale is controlled by the state of brain activity.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cerebrospinal Fluid ; Neurodegeneration ; Neuromodulators ; Perivascular Spaces ; Sleep ; Tissue Clearance; Meningeal Lymphatic Drainage; Extracellular-space; Glymphatic System; Sleep Quality; Pathology; Clearance; Disease; Organs; Mice
ISSN (print) / ISBN
0301-0082
e-ISSN
1873-5118
Journal
Progress in Neurobiology
Quellenangaben
Volume: 229,
Article Number: 102512
Publisher
Elsevier
Publishing Place
The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Tissue Engineering and Regenerative Medicine (ITERM)
Grants
Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
JPND Program
Simons Foundation
Human Frontier Science Program
US Army Research Office
National Institutes of Health
Novo Nordisk Foundation
Lundbeck Foundation
JPND Program
Simons Foundation
Human Frontier Science Program
US Army Research Office
National Institutes of Health
Novo Nordisk Foundation
Lundbeck Foundation