PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Ziegler, K.A.* ; Ahles, A.* ; Dueck, A.* ; Esfandyari, D.* ; Pichler, P.* ; Weber, K.* ; Kotschi, S.* ; Bartelt, A. ; Sinicina, I.* ; Graw, M.* ; Leonhardt, H.* ; Weckbach, L.T.* ; Massberg, S.* ; Schifferer, M.* ; Simons, M.* ; Höher, L. ; Luo ; Ertürk, A. ; Schiattarella, G.G.* ; Sassi, Y.* ; Misgeld, T.* ; Engelhardt, S.*

Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease.

Science 381, 285-290 (2023)
Publ. Version/Full Text DOI PMC
Free by Publisher
Open Access Green as soon as Postprint is submitted to ZB.
Disruption of the physiologic sleep-wake cycle and low melatonin levels frequently accompany cardiac disease, yet the underlying mechanism has remained enigmatic. Immunostaining of sympathetic axons in optically cleared pineal glands from humans and mice with cardiac disease revealed their substantial denervation compared with controls. Spatial, single-cell, nuclear, and bulk RNA sequencing traced this defect back to the superior cervical ganglia (SCG), which responded to cardiac disease with accumulation of inflammatory macrophages, fibrosis, and the selective loss of pineal gland-innervating neurons. Depletion of macrophages in the SCG prevented disease-associated denervation of the pineal gland and restored physiological melatonin secretion. Our data identify the mechanism by which diurnal rhythmicity in cardiac disease is disturbed and suggest a target for therapeutic intervention.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
56.900
0.000
8
4
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Superior Cervical-ganglion; Expression; Transgene; Melatonin; Neurons; Atrial
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Journal Science
Quellenangaben Volume: 381, Issue: 6655, Pages: 285-290 Article Number: , Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Publishing Place 1200 New York Ave, Nw, Washington, Dc 20005 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
Institute for Tissue Engineering and Regenerative Medicine (ITERM)
POF-Topic(s) 90000 - German Center for Diabetes Research
30205 - Bioengineering and Digital Health
Research field(s) Helmholtz Diabetes Center
Enabling and Novel Technologies
PSP Element(s) G-501900-251
G-505800-001
Grants TUM
European Research Council
Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
DZHK (German Centre for Cardiovascular Research)
DFG
German Cardiac Society
Munich Center for Systems Neurology
ERC under the European Union
German Center for Neurodegenerative Diseases (DZNE)
BMBF
DOI 10.1126/science.abn6366
WOS ID 001046763100024
Scopus ID 85165488796
PubMed ID 37471539
Erfassungsdatum 2023-10-06
[➜Report correction]