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Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes.
Nucleus 14:2229642 (2023)
In eukaryotic genomes, hundreds to thousands of potential start sites of DNA replication named origins are dispersed across each of the linear chromosomes. During S-phase, only a subset of origins is selected in a stochastic manner to assemble bidirectional replication forks and initiate DNA synthesis. Despite substantial progress in our understanding of this complex process, a comprehensive 'identity code' that defines origins based on specific nucleotide sequences, DNA structural features, the local chromatin environment, or 3D genome architecture is still missing. In this article, we review the genetic and epigenetic features of replication origins in yeast and metazoan chromosomes and highlight recent insights into how this flexibility in origin usage contributes to nuclear organization, cell growth, differentiation, and genome stability.
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Publication type
Article: Journal article
Document type
Review
Keywords
3d Genome Organization ; Dna Replication ; Chromatin Structure ; Histone Modifications ; Origin Clustering ; Origins Of Replication ; Replication Timing; Protein Phosphatase 1; Lagging-strand Synthesis; Site-specific Initiation; G-quadruplex Binding; Saccharomyces-cerevisiae; Nucleosome Occupancy; Modulates Replication; Chromatin-structure; Dynamic Changes; Timing Program
ISSN (print) / ISBN
1949-1034
e-ISSN
1949-1042
Journal
Nucleus
Quellenangaben
Volume: 14,
Issue: 1,
Article Number: 2229642
Publisher
Taylor & Francis
Publishing Place
530 Walnut Street, Ste 850, Philadelphia, Pa 19106 Usa
Non-patent literature
Publications
Institute(s)
Institute of Epigenetics and Stem Cells (IES)
Grants
Helmholtz Association