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Neurotoxin-derived optical probes for biological and medical imaging.
Mol. Imaging Biol. 25, 799-814 (2023)
The superb specificity and potency of biological toxins targeting various ion channels and receptors are of major interest for the delivery of therapeutics to distinct cell types and subcellular compartments. Fused with reporter proteins or labelled with fluorophores and nanocomposites, animal toxins and their detoxified variants also offer expanding opportunities for visualisation of a range of molecular processes and functions in preclinical models, as well as clinical studies. This article presents state-of-the-art optical probes derived from neurotoxins targeting ion channels, with discussions of their applications in basic and translational biomedical research. It describes the design and production of probes and reviews their applications with advantages and limitations, with prospects for future improvements. Given the advances in imaging tools and expanding research areas benefiting from the use of optical probes, described here resources should assist the discovery process and facilitate high-precision interrogation and therapeutic interventions.
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Publication type
Article: Journal article
Document type
Review
Keywords
Advanced Biomaterials ; Animal Toxins ; Fluorescent Probes ; Icg ; Ion Channels ; Optical Imaging ; Visualisation; Voltage-gated Sodium; Chlorotoxin-like Peptide; Clc Chloride Channels; Union-of-pharmacology; Motor-nerve Terminals; Omega-agatoxin Iva; Calcium-channels; Ion Channels; Trp Channels; Potassium Channels
Language
english
Publication Year
2023
HGF-reported in Year
2023
ISSN (print) / ISBN
1536-1632
e-ISSN
1860-2002
Journal
Molecular Imaging and Biology
Quellenangaben
Volume: 25,
Issue: 5,
Pages: 799-814
Publisher
Elsevier
Publishing Place
One New York Plaza, Suite 4600, New York, Ny, United States
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s)
30205 - Bioengineering and Digital Health
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-505500-001
Grants
Research Excellent Framework Program
University of Greenwich
University of Greenwich
WOS ID
001032007500001
Scopus ID
85165130302
PubMed ID
37468801
Erfassungsdatum
2023-10-06