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Ergen, P.H.* ; Shorter, S.* ; Ntziachristos, V. ; Ovsepian, S.V.*

Neurotoxin-derived optical probes for biological and medical imaging.

Mol. Imaging Biol. 25, 799-814 (2023)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
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The superb specificity and potency of biological toxins targeting various ion channels and receptors are of major interest for the delivery of therapeutics to distinct cell types and subcellular compartments. Fused with reporter proteins or labelled with fluorophores and nanocomposites, animal toxins and their detoxified variants also offer expanding opportunities for visualisation of a range of molecular processes and functions in preclinical models, as well as clinical studies. This article presents state-of-the-art optical probes derived from neurotoxins targeting ion channels, with discussions of their applications in basic and translational biomedical research. It describes the design and production of probes and reviews their applications with advantages and limitations, with prospects for future improvements. Given the advances in imaging tools and expanding research areas benefiting from the use of optical probes, described here resources should assist the discovery process and facilitate high-precision interrogation and therapeutic interventions.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Advanced Biomaterials ; Animal Toxins ; Fluorescent Probes ; Icg ; Ion Channels ; Optical Imaging ; Visualisation; Voltage-gated Sodium; Chlorotoxin-like Peptide; Clc Chloride Channels; Union-of-pharmacology; Motor-nerve Terminals; Omega-agatoxin Iva; Calcium-channels; Ion Channels; Trp Channels; Potassium Channels
ISSN (print) / ISBN 1536-1632
e-ISSN 1860-2002
Journal Molecular Imaging and Biology
Quellenangaben Volume: 25, Issue: 5, Pages: 799-814 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place One New York Plaza, Suite 4600, New York, Ny, United States
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
Grants Research Excellent Framework Program
University of Greenwich