PuSH - Publication Server of Helmholtz Zentrum München: RNA trafficking and subcellular localization-a review of mechanisms, experimental and predictive methodologies.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Wang, J.* ; Horlacher, M. ; Cheng, L.* ; Winther, O.*

RNA trafficking and subcellular localization-a review of mechanisms, experimental and predictive methodologies.

Brief. Bioinform. 24:14 (2023)

Publ. Version/Full Text

DOI

PMC

	Open Access Gold (Paid Option)

Abstract
Metrics
Extra information

RNA localization is essential for regulating spatial translation, where RNAs are trafficked to their target locations via various biological mechanisms. In this review, we discuss RNA localization in the context of molecular mechanisms, experimental techniques and machine learning-based prediction tools. Three main types of molecular mechanisms that control the localization of RNA to distinct cellular compartments are reviewed, including directed transport, protection from mRNA degradation, as well as diffusion and local entrapment. Advances in experimental methods, both image and sequence based, provide substantial data resources, which allow for the design of powerful machine learning models to predict RNA localizations. We review the publicly available predictive tools to serve as a guide for users and inspire developers to build more effective prediction models. Finally, we provide an overview of multimodal learning, which may provide a new avenue for the prediction of RNA localization.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords Rna ; Localization ; Machine Learning ; Multimodality ; Subcellular; Bicoid Messenger-rna; Motor-neuron Smn; Binding Protein; Gene-expression; Spatial-organization; Local Translation; Global Analysis; Cell Polarity; Reveals; Transport

ISSN (print) / ISBN 1467-5463

e-ISSN 1477-4054

Journal Briefings in Bioinformatics

Quellenangaben Volume: 24, Issue: 5, Article Number: 14

Publisher Oxford University Press

Publishing Place Great Clarendon St, Oxford Ox2 6dp, England

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Computational Biology (ICB)

Grants Danish National Research Foundation
Novo Nordisk Foundation
China Scholarship Council (CSC)