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Daniels, M. ; Fischer-Posovszky, P.* ; Boschmann, M.* ; Jumpertz von Schwartzenberg, R. ; Müller, T.D. ; Sandforth, L. ; Frank-Podlech, S. ; Hülskämper, S. ; Peter, A. ; Wabitsch, M.* ; Jordan, J.* ; Birkenfeld, A.L.

Atrial natriuretic peptide and leptin interactions in healthy men.

Front. Endocrin. 14:1195677 (2023)
Postprint DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
INTRODUCTION: Atrial natriuretic peptide (ANP), a hormone secreted from the heart, controls cardiovascular and renal functions including arterial blood pressure and natriuresis. ANP also exerts metabolic effects in adipose tissue, liver and skeletal muscle, and interacts with the secretion of adipokines. We tested the hypothesis that ANP lowers concentrations of the anorexigenic adipokine leptin in healthy humans in vivo. METHODS: Human ANP or matching placebo was infused intravenously (iv) into healthy men in a controlled clinical trial. RESULTS: Within 135 minutes of iv ANP infusion, we observed an acute decrease in plasma leptin levels compared to controls. Free fatty acids markedly increased with ANP infusion in vivo, indicating activated lipolysis. In human SGBS adipocytes, ANP suppressed leptin release. DISCUSSION: The study shows that the cardiac hormone ANP reduces the levels of the anorexigenic adipokine leptin in healthy humans, providing further support for ANP as a cardiomyokine in a heart - adipose tissue axis. (registered in the German Clinical Trials Register and the WHO International Clinical Trials Registry Platform was granted under DRKS00024559).
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Anp ; Atrial Natriuretic Peptide ; Heart Failure ; Insulin Resistance ; Leptin ; Lipolysis ; Obesity; Secretion; Capacity
ISSN (print) / ISBN 1664-2392
e-ISSN 1664-2392
Journal Frontiers in Endocrinology
Quellenangaben Volume: 14, Issue: , Pages: , Article Number: 1195677 Supplement: ,
Publisher Frontiers
Publishing Place Lausanne
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute of Diabetes and Obesity (IDO)
Grants Helmholtz Association by a Helmholtz Young Investigator Group
German Center for Diabetes Research (DZD)
German Research Foundation
Deutsche Forschungsgemeinschaft