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Meyhöfer, S.* ; Chamorro, R.* ; Hallschmid, M. ; Spyra, D.* ; Klinsmann, N.* ; Schultes, B.* ; Lehnert, H.* ; Meyhöfer, S.M.* ; Wilms, B.*

Late, but not early, night sleep loss compromises neuroendocrine appetite regulation and the desire for food.

Nutrients 15:12 (2023)

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OBJECTIVE: There is evidence that reduced sleep duration increases hunger, appetite, and food intake, leading to metabolic diseases, such as type 2 diabetes and obesity. However, the impact of sleep timing, irrespective of its duration and on the regulation of hunger and appetite, is less clear. We aimed to evaluate the impact of sleep loss during the late vs. early part of the night on the regulation of hunger, appetite, and desire for food. METHODS: Fifteen normal-weight ([mean ± SEM] body-mass index: 23.3 ± 0.4 kg/m²) healthy men were studied in a randomized, balanced, crossover design, including two conditions of sleep loss, i.e., 4 h sleep during the first night-half ('late-night sleep loss'), 4 h sleep during the second night-half ('early-night sleep loss'), and a control condition with 8h sleep ('regular sleep'), respectively. Feelings of hunger and appetite were assessed through visual analogue scales, and plasma ghrelin and leptin were measured from blood samples taken before, during, and after night-time sleep. RESULTS: Ghrelin and feelings of hunger and appetite, as well as the desire for food, were increased after 'late-night sleep loss', but not 'early-night sleep loss', whereas leptin remained unaffected by the timing of sleep loss. CONCLUSIONS: Our data indicate that timing of sleep restriction modulates the effects of acute sleep loss on ghrelin and appetite regulation in healthy men. 'Late-night sleep loss' might be a risk factor for metabolic diseases, such as obesity and type 2 diabetes. Thereby, our findings highlight the metabolic relevance of chronobiological sleep timing.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Appetite Regulation ; Ghrelin ; Healthy Men ; Leptin ; Sleep Loss ; Sleep Timing; Social Jetlag; Leptin Levels; Energy-expenditure; Ghrelin Levels; Caloric-intake; Restriction; Duration; Hunger; Metaanalysis; Deprivation

ISSN (print) / ISBN 2072-6643

e-ISSN 2072-6643

Journal Nutrients

Quellenangaben Volume: 15, Issue: 9, Article Number: 12

Publisher MDPI

Publishing Place Basel

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)

Grants Vicerrectoria de Investigacion y Desarrollo (VID), Universidad de Chile
Chilean National Commission for Scientific and Technological Research
German Federal Ministry of Education and Research (BMBF)
Deutsche Forschungsgemeinschaft