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Hinney, A.* ; Scherag, A.* ; Jarick, I.* ; Albayrak, Ö.* ; Pütter, C.* ; Pechlivanis, S.* ; Dauvermann, M.R.* ; Beck, S.* ; Weber, H.* ; Scherag, S.* ; Nguyen, T.T.* ; Volckmar, A.L.* ; Knoll, N.* ; Faraone, S.V.* ; Neale, B.M.* ; Franke, B.* ; Cichon, S.* ; Hoffmann, P.* ; Nöthen, M.M.* ; Schreiber, S.* ; Jöckel, K.-H.* ; Wichmann, H.-E. ; Freitag, C.* ; Lempp, T.* ; Meyer, J.* ; Gilsbach, S.* ; Herpertz-Dahlmann, B.* ; Sinzig, J.* ; Lehmkuhl, G.* ; Renner, T.J.* ; Warnke, A.* ; Romanos, M.* ; Lesch, K.P.* ; Reif, A.* ; Schimmelmann, B.G.* ; Hebebrand, J.* ; Psychiatric GWAS Consortium ADHD Subgroup (*)

Genome-wide association study in German patients with attention deficit/hyperactivity disorder.

Am. J. Med. Genet. B 156B, 888-897 (2011)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The heritability of attention deficit hyperactivity disorder (ADHD) is approximately 0.8. Despite several larger scale attempts, genome-wide association studies (GWAS) have not led to the identification of significant results. We performed a GWAS based on 495 German young patients with ADHD (according to DSM-IV criteria; Human660W-Quadv1; Illumina, San Diego, CA) and on 1,300 population-based adult controls (HumanHap550v3; Illumina). Some genes neighboring the single nucleotide polymorphisms (SNPs) with the lowest P-values (best P-value: 8.38 × 10(-7)) have potential relevance for ADHD (e.g., glutamate receptor, metabotropic 5 gene, GRM5). After quality control, the 30 independent SNPs with the lowest P-values (P-values ≤ 7.57 × 10(-5) ) were chosen for confirmation. Genotyping of these SNPs in up to 320 independent German families comprising at least one child with ADHD revealed directionally consistent effect-size point estimates for 19 (10 not consistent) of the SNPs. In silico analyses of the 30 SNPs in the largest meta-analysis so far (2,064 trios, 896 cases, and 2,455 controls) revealed directionally consistent effect-size point estimates for 16 SNPs (11 not consistent). None of the combined analyses revealed a genome-wide significant result. SNPs in previously described autosomal candidate genes did not show significantly lower P-values compared to SNPs within random sets of genes of the same size. We did not find genome-wide significant results in a GWAS of German children with ADHD compared to controls. The second best SNP is located in an intron of GRM5, a gene located within a recently described region with an infrequent copy number variation in patients with ADHD.
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Publication type Article: Journal article
Document type Scientific Article
Keywords psychiatric; children; early onset; homogeneous
Language english
Publication Year 2011
HGF-reported in Year 2011
ISSN (print) / ISBN 1552-4841
e-ISSN 0148-7299
Journal American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Quellenangaben Volume: 156B, Issue: 8, Pages: 888-897 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Hoboken, NJ
Reviewing status Peer reviewed
Institute(s) Research Unit Molecular Epidemiology (AME)
Institute of Epidemiology (EPI)
POF-Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504200-001
G-503900-001
PubMed ID 22012869
DOI 10.1002/ajmg.b.31246
Scopus ID 80054872366
Erfassungsdatum 2011-12-23
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