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Open Access Green as soon as Postprint is submitted to ZB.
Regulation of mammalian totipotency: A molecular perspective from in vivo and in vitro studies.
Curr. Opin. Genet. Dev. 81:102083 (2023)
In mammals, cells acquire totipotency at fertilization. Embryonic genome activation (EGA), which occurs at the 2-cell stage in the mouse and 4- to 8-cell stage in humans, occurs during the time window at which embryonic cells are totipotent and thus it is thought that EGA is mechanistically linked to the foundations of totipotency. The molecular mechanisms that lead to the establishment of totipotency and EGA had been elusive for a long time, however, recent advances have been achieved with the establishment of new cell lines with greater developmental potential and the application of novel low-input high-throughput techniques in embryos. These have unveiled several principles of totipotency related to its epigenetic makeup but also to characteristic features of totipotent cells. In this review, we summarize and discuss current views exploring some of the key drivers of totipotency from both in vitro cell culture models and embryogenesis in vivo.
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Publication type
Article: Journal article
Document type
Review
Keywords
Chromatin Assembly Factor-1; Zygotic Genome Activation; Embryonic-like Cells; Gene-expression; Stem-cells; Mouse; Dux; Transcription; Populations; Metabolism
ISSN (print) / ISBN
0959-437X
e-ISSN
1879-0380
Quellenangaben
Volume: 81,
Article Number: 102083
Publisher
Elsevier
Publishing Place
84 Theobalds Rd, London Wc1x 8rr, England
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epigenetics and Stem Cells (IES)
Grants
German Research Foundation (DFG) through the CRC Chromatin Dynamics
National Institutes of Health (NIH)
Helmholtz Association
National Institutes of Health (NIH)
Helmholtz Association