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Nakatani, T. ; Torres-Padilla, M.E.

Regulation of mammalian totipotency: A molecular perspective from in vivo and in vitro studies.

Curr. Opin. Genet. Dev. 81:102083 (2023)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
In mammals, cells acquire totipotency at fertilization. Embryonic genome activation (EGA), which occurs at the 2-cell stage in the mouse and 4- to 8-cell stage in humans, occurs during the time window at which embryonic cells are totipotent and thus it is thought that EGA is mechanistically linked to the foundations of totipotency. The molecular mechanisms that lead to the establishment of totipotency and EGA had been elusive for a long time, however, recent advances have been achieved with the establishment of new cell lines with greater developmental potential and the application of novel low-input high-throughput techniques in embryos. These have unveiled several principles of totipotency related to its epigenetic makeup but also to characteristic features of totipotent cells. In this review, we summarize and discuss current views exploring some of the key drivers of totipotency from both in vitro cell culture models and embryogenesis in vivo.
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Publication type Article: Journal article
Document type Review
Keywords Chromatin Assembly Factor-1; Zygotic Genome Activation; Embryonic-like Cells; Gene-expression; Stem-cells; Mouse; Dux; Transcription; Populations; Metabolism
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 0959-437X
e-ISSN 1879-0380
Journal Current Opinion in Genetics & Development
Quellenangaben Volume: 81, Issue: , Pages: , Article Number: 102083 Supplement: ,
Publisher Elsevier
Publishing Place 84 Theobalds Rd, London Wc1x 8rr, England
Reviewing status Peer reviewed
Institute(s) Institute of Epigenetics and Stem Cells (IES)
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Stem Cell and Neuroscience
PSP Element(s) G-506200-001
Grants German Research Foundation (DFG) through the CRC Chromatin Dynamics
National Institutes of Health (NIH)
Helmholtz Association
DOI 10.1016/j.gde.2023.102083
WOS ID 001040869700001
Scopus ID 85164212924
PubMed ID 37421903
Erfassungsdatum 2023-10-06
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