Most obese patients would benefit from 5–10 % of weight loss but fail
when using non-surgical approaches. The recent development of two
anti-obesity drugs may change that therapeutic gap. Patients receiving
long-acting glucagon-like peptide 1 (GLP1) agonist semaglutide achieve
weight loss above 10 %. With tirzepatide, a co-agonist for GLP-1 and the
gastric inhibitory polypeptide (GIP) receptor, more than 50 % of the
patients even lose above 20 %, which rivals the efficacy of surgical
interventions.