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Hvidtfeldt, U.A.* ; Chen, J.* ; Rodopoulou, S.* ; Strak, M.* ; de Hoogh, K.* ; Andersen, Z.J.* ; Bellander, T.* ; Brandt, J.* ; Forastiere, F.* ; Brynedal, B.* ; Hertel, O.* ; Hoffmann, B.* ; Katsouyanni, K.* ; Ketzel, M.* ; Leander, K.* ; Magnusson, P.K.E.* ; Nagel, G.* ; Pershagen, G.* ; Rizzuto, D.* ; Samoli, E.* ; So, R.* ; Stafoggia, M.* ; Tjønneland, A.* ; Weinmayr, G.* ; Wolf, K. ; Zitt, E.* ; Brunekreef, B.* ; Hoek, G.* ; Raaschou-Nielsen, O.*

Multiple myeloma risk in relation to long-term air pollution exposure - A pooled analysis of four European cohorts.

Environ. Res. 239:117230 (2023)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Background: Air pollution is a growing concern worldwide, with significant impacts on human health. Multiple myeloma is a type of blood cancer with increasing incidence. Studies have linked air pollution exposure to various types of cancer, including leukemia and lymphoma, however, the relationship with multiple myeloma incidence has not been extensively investigated. Methods: We pooled four European cohorts (N = 234,803) and assessed the association between residential exposure to nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), and ozone (O3) and multiple myeloma. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. Results: During 4,415,817 person-years of follow-up (average 18.8 years), we observed 404 cases of multiple myeloma. The results of the fully adjusted linear analyses showed hazard ratios (95% confidence interval) of 0.99 (0.84, 1.16) per 10 μg/m³ NO2, 1.04 (0.82, 1.33) per 5 μg/m³ PM2.5, 0.99 (0.84, 1.18) per 0.5 10−5 m−1 BCE, and 1.11 (0.87, 1.41) per 10 μg/m³ O3. Conclusions: We did not observe an association between long-term ambient air pollution exposure and incidence of multiple myeloma.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Air Pollution ; Multiple Myeloma ; Nitrogen Dioxide ; Ozone ; Particulate Matter; Cancer; Men; Completeness; Population; Dioxide; Smoking; Models; Health; Women; Pm2.5
ISSN (print) / ISBN 0013-9351
e-ISSN 1096-0953
Journal Environmental Research
Quellenangaben Volume: 239, Issue: Pt 1, Pages: , Article Number: 117230 Supplement: ,
Publisher Elsevier
Publishing Place San Diego, Calif.
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology II (EPI2)
Grants United States Environmental Protection Agency (EPA)