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Gopalakrishnan, J.* ; Feistel, K.* ; Friedrich, B.M.* ; Grapin-Botton, A. ; Jurisch-Yaksi, N.* ; Mass, E.* ; Mick, D.U.* ; Müller, R.U.* ; May-Simera, H.* ; Schermer, B.* ; Schmidts, M.* ; Walentek, P.* ; Wachten, D.*

Emerging principles of primary cilia dynamics in controlling tissue organization and function.

EMBO J. 42, e113891 (2023)
Publ. Version/Full Text DOI PMC
Open Access Hybrid
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Primary cilia project from the surface of most vertebrate cells and are key in sensing extracellular signals and locally transducing this information into a cellular response. Recent findings show that primary cilia are not merely static organelles with a distinct lipid and protein composition. Instead, the function of primary cilia relies on the dynamic composition of molecules within the cilium, the context-dependent sensing and processing of extracellular stimuli, and cycles of assembly and disassembly in a cell- and tissue-specific manner. Thereby, primary cilia dynamically integrate different cellular inputs and control cell fate and function during tissue development. Here, we review the recently emerging concept of primary cilia dynamics in tissue development, organization, remodeling, and function.
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Publication type Article: Journal article
Document type Review
Keywords Cilia Dynamics ; Ciliary Signaling ; Cilium Disassembly ; Primary Cilia ; Tissue Organization; Protein-coupled Receptors; Bardet-biedl-syndrome; Retinal-pigment Epithelium; Left-right Asymmetry; Planar Cell Polarity; Ift-a Complex; Intraflagellar Transport; Extracellular Vesicles; Leftward Flow; Proteomic Analysis
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 0261-4189
e-ISSN 1460-2075
Journal EMBO Journal, The
Quellenangaben Volume: 42, Issue: 21, Pages: e113891 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Heidelberg, Germany
Reviewing status Peer reviewed
Institute(s) Institute of Pancreatic Islet Research (IPI)
POF-Topic(s) 90000 - German Center for Diabetes Research
PSP Element(s) A-502600-001
Grants European Research Council
DOI 10.15252/embj.2023113891
WOS ID 001070676500001
Scopus ID 85172013611
PubMed ID 37743763
Erfassungsdatum 2023-10-18
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