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Emerging principles of primary cilia dynamics in controlling tissue organization and function.
EMBO J. 42, e113891 (2023)
Publ. Version/Full Text
DOI
PMC
Primary cilia project from the surface of most vertebrate cells and are key in sensing extracellular signals and locally transducing this information into a cellular response. Recent findings show that primary cilia are not merely static organelles with a distinct lipid and protein composition. Instead, the function of primary cilia relies on the dynamic composition of molecules within the cilium, the context-dependent sensing and processing of extracellular stimuli, and cycles of assembly and disassembly in a cell- and tissue-specific manner. Thereby, primary cilia dynamically integrate different cellular inputs and control cell fate and function during tissue development. Here, we review the recently emerging concept of primary cilia dynamics in tissue development, organization, remodeling, and function.
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Publication type
Article: Journal article
Document type
Review
Keywords
Cilia Dynamics ; Ciliary Signaling ; Cilium Disassembly ; Primary Cilia ; Tissue Organization; Protein-coupled Receptors; Bardet-biedl-syndrome; Retinal-pigment Epithelium; Left-right Asymmetry; Planar Cell Polarity; Ift-a Complex; Intraflagellar Transport; Extracellular Vesicles; Leftward Flow; Proteomic Analysis
ISSN (print) / ISBN
0261-4189
e-ISSN
1460-2075
Journal
EMBO Journal, The
Quellenangaben
Volume: 42,
Issue: 21,
Pages: e113891
Publisher
Wiley
Publishing Place
Heidelberg, Germany
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Pancreatic Beta Cell Research (IPI)
Grants
European Research Council